Hormone therapy - interprete1929

Drug or Chemo Therapy Associated with Invasive (Infiltrating) Ductal Carcinoma . Posted on October 1, 2017 View this journey (0 Experiences)

I switched from Tamoxifen to Arimidex. Side effect: deep depression.

Easy to Do: Neutral/NA
Minimal Side Effects: Strongly Disagree
Minimal Impact to Daily Life: Strongly Disagree
6 Comments
  • cak61's Avatar
    cak61

    If you were tolerating Tamoxifen and there is no medical reason for you to switch (blood clot risk), go back on Tamoxifen. That's what I did.
    The aromatase inhibitors offer only a very slight improvement in reducing the recurrence rate.
    Both have side effects and risks.

    about 1 month ago
  • Dltmoll's Avatar
    Dltmoll

    Talk to your doctor. Many of us have had to switch AIs because of various side effects, which in many cases decreased as a result. Aromasin (Exemestane) works differently than the other two, so may be a better fit for you.

    about 1 month ago
  • Jesse0218's Avatar
    Jesse0218

    I was on Arimidex first but it gave me a rash. After about 3 1/2 months, I finally said something to my doctor about it.
    She took me off everything while the rash cleared up, then put me on Femara. The side effect I get with that is hot flashes. Really bad hot flashes. I never had any problems with hot flashes when I went through my change, but with the Femara, it was a whole other story. They tried Vit E first and it didn't do anything at all to help so they put me on Effexor. She said Effexor is normally used for depression but they find it works better for hot flashes. And, it does work for me. Doesn't do anything for my mood because I'm not depressed but really helps control the hot flashes.
    I'm too old for Tamoxifen too.

    about 1 month ago
  • Nanzee's Avatar
    Nanzee

    I’ve been on Arimidex for 9 months, and I’m fighting depression too. I don’t know if it has anything to do with the Arimidex. I guess the only way to find out is to stop the med. How did you make the connection, and how long till you started to feel better?

    about 1 month ago
  • cak61's Avatar
    cak61

    Jesse0218, no one is too old for Tamoxifen. If you are premenopausal you cannot use an aromatase inhibitor, but they have not been around all that long and before that everyone took Tamoxifen. I see so many women having problems with bone density from the AI's and are then put on another medication for that problem.
    Tamoxifin has it's own risks.
    I also suffered horribly with hot flashes on the AI's. Effexor only helped for a few months, so doctor put me back on Tamoxifen and they were much more tolerable.

    about 1 month ago
  • Jesse0218's Avatar
    Jesse0218

    cak61, thanks for clearing this up for me. I've been on the Effexor and Femara for a couple years without serious problems like the Arimidex. So, I'd guess, I'll be on these until I can stop someday.

    about 1 month ago

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