• FLymphoma18's Avatar

    FLymphoma18 asked a questionNon-Hodgkin Lymphoma (NHL)

    Are there any treatments using stem cells

    • po18guy's Avatar
      po18guy

      Can you be a bit more specific? "Stem cells" relates to immature cells produced in the bone marrow. They are involved in the two major classes of stem cell transplants: autologous and allogeneic. Autologous transplants use your own cells, which are harvested and re-introduced to your bloodstream after your marrow/immune system has been neutralized. Allogeneic transplants use blood stem cells from a donor, whether related to you or not, again after your original immune system has been neutralized or eliminated.

      Is doctor proposing a stem cell transplant in your case?

      6 months ago
    • FLymphoma18's Avatar
      FLymphoma18

      I was not proposed anything related to this I have been hearing so much about how this can held people with knee and hip pain. Just wondering. because they are talking about going to start chemo and I hate that idea.

      6 months ago
    • po18guy's Avatar
      po18guy

      Oh, that would probably be an allogeneic stem cell transplant in cases of serious auto-immune disease. There are many auto-immune diseases and conditions (from Psoriasis to Lupus to Rheumatoid Arthritis) which involve the patient's own immune system attacking healthy cells. The reasons for this are not completely understood.

      https://en.wikipedia.org/wiki/Autoimmune_disease

      However, prior to such a radical procedure as a stem cell transplant, there are many new drugs in the "inhibitor" class which regulate one's own immune system so as to reduce or eliminate the body's attack on itself. I would think that it is prudent to try the various immune modulating drugs before undergoing a transplant.

      As to chemotherapy, there is far less to fear these days than even in the recent past. New drugs have entered the market at a steady rate and non-chemo "biological" drugs are gaining popularity. In cases of follicular lymphoma, the standard is often some modification of the age-old CHOP regimen used against lymphoma. Commonly, the new drug Rituxan is added, to make R-CHOP.

      On occasion, a substantially different variation is administered. It is known as B-R, for Bendamustine plus Rituxan. Both regimens are generally far superior to th "old guard" chemo regimens.

      Oh, and as to chemo, since August 2008, I have received 20 drugs in something like 11 or 12 regimens, 19 of those drugs anti-cancer - either chemotherapy of biological. Add to that full body irradiation and an allogeneic stem cell transplant. I am still here, and delighted to be anywhere at all.

      6 months ago