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    In case anyone was planning on trying to get some of this medicine that is being "tested" on its efficacy for treating covid-19. This from a doctor.

    Chloroquine and hydroxychloroquine, that have proven effectiveness in the treatment of diseases such as malaria, lupus erythematosus, some forms of arthritis, and other maladies that have shown promising, but not proven, results in treating COVID-19.
    As a result of this news, some prescribers have written prescriptions for these drugs for friends, families, and even themselves as prophylactic measures, thus depleting the stocks for both patients with known indications for treatment using these drugs and also potentially for individuals confirmed as having COVID-19.
    Chloroquine and hydroxychloroquine use have a potentially significant risk. These agents have a narrow therapeutic window (the toxic dose is not much greater than the therapeutic dose). Side effects include eye, neurological and cardiac toxicities. It is therefore critical not to take these meds without physician evaluation and prescription.
    This information was prepared by Dr Glen I. Reeves. A radiation oncologist, Arlington VA
    Read more at Read more at https://laryngectomeenewsletter.blogspot.com/
    Itzhak Brook MD

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    When Prostate Cancer Spreads

    Prostate cancer starts when cells in the prostate gland grow out of control. Those cells can spread to other parts of the body and affect healthy tissue.

    This can happen for several reasons.

    Early Treatment Failure
    When prostate cancer is discovered early, treatment usually works. Most men are able to live cancer-free for many years.

    But sometimes, treatment doesn't work and prostate cancer can slowly grow. This can happen after surgery (called a radical prostatectomy) or radiation therapy.

    Sometimes called a chemical recurrence, it's when the cancer survives inside the prostate or reappears and spreads to other tissues and organs. The cancer is usually microscopic and grows very slowly.

    You and your doctor will work together to keep an eye on the cancer as it grows. You may come up with a new treatment plan.

    Watchful Waiting
    Because prostate cancer cells usually grow very slowly, some men might not need treatment right away. Your doctor might suggest something called "watchful waiting" or "active surveillance." Your doctor will still do regular blood tests and exams to keep an eye on your cancer.

    This plan is usually for men who don't have symptoms and whose cancer is expected to grow slowly.

    The risk with this approach is that the cancer might grow and spread between checkups. This could limit which treatment you could take and if your cancer can be cured.

    Treatment Issues
    When you're diagnosed with cancer, like any medical issue, it's important that you follow your treatment plan. That can mean scheduling regular checkups or, if radiation therapy is part of your regimen, being sure to go to all scheduled radiation visits.

    If you miss some of them, you may have a greater chance that your cancer will spread.

    In one study, for example, men who missed two or more sessions during their treatment had a greater chance that their cancer would come back. That was even though they eventually finished their course of radiation.

    Late Diagnosis
    Experts disagree on whether all men should get tested for prostate cancer and at what age screenings and the discussions about them should take place. Exams such as a prostate-specific antigen (PSA) test can help find cancer early. But there are questions about if the benefits of screening tests always outweigh the risks.

    Some groups suggest that men at a normal risk for prostate cancer should have prostate screening tests when they turn 50. Some men might want to get tests earlier if they have risk factors that make them more likely to get prostate cancer.

    The U.S. Preventive Services Task Force (USPSTF) says that testing may be appropriate for some men age 55 to 69. They recommend that men talk to their doctor to discuss the potential risks and benefits of being tested.

    The American Cancer Society recommends starting screenings at age 50, possibly earlier if at high risk. But first, men should discuss the pros and cons of the PSA test with their doctor to decide if it's right for them.

    The American Urological Association says if you are a man age 55 to 69, you should talk to your doctor about the benefits and risks of a PSA test. The group also adds:

    PSA screening in men under age 40 is not recommended.
    Routine screening in men between ages 40 and 54 at average risk is not recommended.
    To reduce the harms of screening, a routine screening interval of two years or more may be preferred over annual screening in those men who have decided on screening after a discussion with their doctor. As compared to annual screening, it is expected that screening intervals of two years preserve the majority of the benefits and reduce over diagnosis and false positives.
    Routine PSA screening is not recommended in men for most men over 70 or any man with less than a 10 to 15 year life expectancy.
    There are some men age 70 and older who are in excellent health that may benefit from prostate cancer screening.
    Early prostate cancer usually has no symptoms. You may go to see the doctor when you have trouble urinating or pain in your hips and back. That's when prostate cancer may be discovered.

    After that, your doctor may find out that your cancer has already spread beyond your prostate. If that's a possibility, you may be asked to take a test like a:

    Bone scan
    CT scan
    PET scan
    Knowing if your cancer has spread will help your doctor work with you to choose your best treatment.

    WebMD Medical Reference

    Reviewed by Melinda Ratini, DO, MS on August 12, 2018

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    Testicular Cancer Survivorship.
    December 9, 2019
    Testicular cancer (TC) is the most common cancer among men aged 18 to 39 years. It is highly curable, with a 10-year relative survival approaching 95% due to effective cisplatin-based chemotherapy. Given the increasing incidence of TC and improved survival, TC survivors (TCS) now account for approximately 4% of all US male cancer survivors. They have also become a valuable cohort for adult-onset cancer survivorship research, given their prolonged survival. Commensurately, long-term treatment-related complications have emerged as important survivorship issues. These late effects include life-threatening conditions, such as second malignant neoplasms and cardiovascular disease. Moreover, TCS can also experience hearing loss, tinnitus, neurotoxicity, nephrotoxicity, pulmonary toxicity, hypogonadism, infertility, anxiety, depression, cognitive impairment, and chronic cancer-related fatigue. Characterization of the number and severity of long-term adverse health outcomes among TCS remains critical to develop risk-stratified, evidence-based follow-up guidelines and to inform the development of preventive measures and interventions. In addition, an improved understanding of the long-term effects of TC treatment on mortality due to noncancer causes and second malignant neoplasms remains paramount. Future research should focus on the continued development of large, well-characterized clinical cohorts of TCS for lifelong follow-up. These systematic, comprehensive approaches can provide the needed infrastructure for further investigation of long-term latency patterns of various medical and psychosocial morbidities and for more in-depth studies investigating associated etiopathogenetic pathways. Studies examining premature physiologic aging may also serve as new frontiers in TC survivorship research.

    Journal of the National Comprehensive Cancer Network : JNCCN. 2019 Dec [Epub]

    Chunkit Fung, Paul C Dinh, Sophie D Fossa, Lois B Travis

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    A story about fighter pilots who suspect they are being diagnosed with prostate cancer in larger numbers than non pilots.

    ‘We are dropping like flies.’ Ex-fighter pilots push for earlier cancer screenings

    Former Air Force and Navy fighter pilots are calling on the military to begin cancer screenings for aviators as young as 30 because of an increase in deaths from the disease that they suspect may be tied to radiation emitted in the cockpit.

    “We are dropping like flies in our 50s from aggressive cancers,” said retired Air Force Col. Eric Nelson, a former F-15E Strike Eagle weapons officer. He cited prostate and esophageal cancers, lymphoma, and glioblastomas that have struck fellow pilots he knew, commanded or flew with.

    Nelson’s prostate cancer was first detected at age 48, just three months after he retired from the Air Force. In his career he has more than 2,600 flying hours, including commanding the 455th Air Expeditionary Group in Bagram, Afghanistan, and as commander of six squadrons of F-15E fighter jets at the 4th Operations Group at Seymour Johnson Air Force Base in North Carolina.

    Last month McClatchy reported on a new Air Force study that reviewed the risk for prostate cancers among its fighter pilots and new Veterans Health Administration data showing that the rate of reported cases of prostate cancers per year among veterans using the VA health care system across all services has risen almost 16 percent since fiscal year 2000.

    The Air Force study also looked at cockpit exposure, finding that “pilots have greater environmental exposure to ultraviolet and ionizing radiation ... (fighter pilots) have unique intra-cockpit exposures to non-ionizing radiation.”

    Retired Navy Cmdr. Mike Crosby served as a radar intercept officer in F-14 fighter jets from 1984 to 1997, accumulating over 2,000 flight hours. He started Veterans Prostate Cancer Awareness Inc. in 2016 after his own prostate cancer diagnosis at age 55.

    “I think there’s been a lot of avoidance in addressing this issue,” he said. Crosby and other pilots who contacted McClatchy said they suspect the cancers in their community may be linked to prolonged exposure in the cockpit to radiation from the radar systems on their advanced jets, or other sources such as from cockpit oxygen generation systems.

    The Centers for Disease Control and Prevention has reported that exposure to some types of radiation can cause cancer, however to date there has been no link established between the specific radiation emitted from radars on these advanced jets and the illnesses pilots are now seeing.

    Navy and Air Force pilots told McClatchy about their battles with cancer, their frustrations about what they saw as the limitations of the Air Force study, and about former pilots who have died from cancer.

    “When you’re 30 years old you need to start screening for prostate cancer, even if it comes out of your own pocket,” Nelson said. “You need to see a urologist once a year. Not your primary care physician, not your flight doc. Pay the money and stick around for your great-grandkids.”

    If the military would begin screening for cancer earlier, “that would save lives,” Nelson said. The military’s health care system, TRICARE, currently covers prostate cancer screenings at age 50 for service members with no family history of the disease, and as young as age 40 if there is a family history of the disease in two or more family members. The pilots who spoke with McClatchy said they did not have a family history of prostate cancer when they were diagnosed.

    Retired Navy Cmdr. Thomas Hill was a career F-4 and F-14 pilot and squadron commanding officer with more than 3,600 flight hours and more than 960 aircraft carrier landings. Hill was 52 when he was diagnosed with a brain tumor. In December 2011, at age 60, he learned he also had esophageal cancer.

    Hill has spent the last two years tracking premature deaths or cancers among former commanding officers of F-14 squadrons. So far he’s found more than a dozen who have either been diagnosed or have died from the disease.

    “God, they’re all my friends,” he said.

    What has frustrated some pilots is that the government has looked into the connection between military service and cancer rates for years, but with mixed results.

    For example, a 2009 peer-reviewed study published by the American Association for Cancer Research looked at cancer rates among service members from 1990 to 2004 and reported in 2009 that “prostate cancer rates in the military were twice those in the general population, and breast cancer rates were 20% to 40% higher.”

    However, a 2011 study published in the peer-reviewed journal “Aviation, Space and Environmental Medicine” found no significant difference in prostate cancer rates between pilots and non-pilots in the military. It’s the same conclusion that the Air Force study found.

    “The Air Force did not ask the right question,” Hill said of the study, which like the 2011 aviation journal review compared cancer rates between pilots and non-pilots but largely did not look at what happened to the pilots’ health after their military careers. The Air Force said its study was limited by lack of access to pilots’ health records after they separated from the military.

    “If they are really going to protect the people who have gone out and served, they need to look at the guys’ health 20 years after they have finished their military careers,” Hill said. His own informal review of fellow pilots showed a similar pattern: cancers usually surfaced about 15 to 20 years after pilots left the military, which would not have been captured by the Air Force review.

    Derek Kaufman, a spokesman for Air Force Materiel Command, said further studies are under consideration. “We have presented potential options for a follow-up study to the Air Force Medical Readiness Agency,” Kaufman said.

    None of the pilots who spoke with McClatchy said a greater risk of cancer would have kept them from flying. They said the military should acknowledge the risk and put additional protections in place for the next generation of military aviators.

    Hill said he’s also worried about the enlisted crew who manned the flight decks of the aircraft carriers.

    “The kids that worked the flight line and the flight deck were exposed eight hours a day to that stuff,” Hill said.

    For future protections for pilots, Crosby said it would be unlikely that the services would retrofit aircraft to add protections against the sources of cockpit radiation, which may be difficult to isolate and would likely add unwanted weight or otherwise affect the performance of the aircraft.

    “If we can’t change it, we need to be responsible and send an alert that people being exposed need to be screened earlier,” Crosby said. “If it’s caught early enough, there’s a lot of procedures that can not just treat (prostate cancer) but cure it.”

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    Breakthrough Treatment for Prostate Cancer

    Cartoonist G.J. Caulkins may have been channeling a musician such as Eric Clapton or Albert King when he captioned an image of a doctor with a guitar telling a startled patient, "At our clinic we take a more 'radical' approach to ultrasound treatment."

    But he wasn't far off the mark — at least when it comes to the benefits of using high-intensity, focused ultrasound (HIFU) to destroy prostate cancer tumors that have not spread.

    A new study in the U.K. tracked 625 men who received the beam-blasting therapy instead of more traditional treatments such as radiation and/or surgery. Reporting results in the journal European Urology, the researchers found:

    • After five years, the cancer survival rate from HIFU was 100 percent. The cancer survival rate from surgery and radiotherapy also is 100 percent at five years.

    • Approximately 1 in 10 men receiving HIFU needed further treatment; also the same as with other treatments.

    The difference? The risk of side effects from the ultrasound therapy — urinary incontinence and erectile dysfunction — are 2 and 15 percent, respectively. Other treatment options are associated with incontinence for 5 to 30 percent of patients and erectile dysfunction for 30 to 60 percent.

    The Food and Drug Administration hasn't yet approved the use of HIFU for prostate cancer treatment (it is allowed for prostate tissue ablation, meaning it can target benign prostate enlargement) — but the FDA is considering it.

    However, some doctors caution that approval will lead to overuse, when most early-stage prostate cancer calls for active surveillance, not treatment. So stay tuned.


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    4 Dangers in Pain Management - By Rick Redner

    Three weeks ago, I herniated a disk, which pinched a nerve. I was in constant pain. My narcotic pain meds didn’t bring my pain to a level low enough to allow me to fall asleep.

    Whether your pain is cancer-related or not, like me, you may find yourself thinking dark thoughts in response to chronic pain. These usually occur in the dead of a sleepless night. Here are a few dangerous options I’ve considered in the last few nights:

    1. Taking more than the prescribed dose
    If your prescribed dosage isn’t working, it’s easy to think taking more will provide better pain relief. According to a post by the American Addiction Centers, “Since 2000, overdose deaths from prescription opioid painkillers have risen dramatically, with more than 14,000 deaths in 2014 attributed to prescription painkiller overdose.” Deciding to take more than your prescribed dosage of pain medication can be a fatal decision. Don’t take more than prescribed.

    2. Mix and match
    If you’ve saved pain medication from a previous illness or injury like I do, the thought of combining your current medication with previous medications is another dangerous temptation. CBS News reported in 2014 that, “In 2013, nearly 60 percent of people using opiate pain medications were taking them along with some other drug in a potentially hazardous combination.” Combining your own medications without medical supervision can cost you your life.

    3. Combining alcohol with pain medication
    According to an article in Scientific American, painkillers and booze are dangerous to mix because both substances slow breathing and obstruct the cough reflex, which can create a “double-whammy effect” that can suffocate you.

    4. Desperate measures
    As an intake assessor for a psychiatric facility, I spoke with a woman suffering from frequent and painful migraine headaches. I advised her to come in for an assessment. She stated she wanted to go on a vacation before coming in for her assessment. She gave me a date to call her back. When I called her back, a family member informed me she’d taken her own life. I was devastated.

    A cousin of mine had chronic and severe back pain. Nothing they tried provided effective pain relief. One day he got into his car with a gun. He shot and killed himself.

    I think the majority of people coping with chronic, severe, sleep-disruptive pain have thought about taking their own lives, at least in passing.

    I’d seen my doctor a week after my pain began. She ordered an X-ray (because Medicare denied an MRI), and I was given a prescription muscle relaxer, pain pills, and a referral to physical therapy. One week later, I asked myself the following question: “Can I continue to live with my current level of pain, sleep disruption, and physical limitations?” The answer was no.

    The next question was, “So what am I going to do to make this situation more tolerable?” The reality is the medical system doesn’t find chronic pain or severe sleep disruption to be medical emergencies. It’s possible you can be stuck with that miserable life-altering situation for weeks at a time.

    I let my doctor know that my pain level was worse. I needed her to get Medicare to approve an MRI. This was necessary if I needed an epidural injection to effectively treat my pain. She put in the request, and my MRI was approved.

    For me, the most important relief I needed was sleep. So, I asked my doctor to prescribe sleep medication that I could take in conjunction with my muscle relaxer and pain medication. It’s amazing how much better I felt after a few hours of consecutive sleep.

    The good news is that I’m getting adequate sleep. The bad news is my pain level keeps getting worse. I have to wait a week for my next appointment to discuss the results of my MRI. It’s more than likely I’ll wait a week or more before I see someone who can give me an epidural injection.

    The whole process can take a month or more. As I said earlier, chronic pain and sleep disturbance are not considered medical emergencies, until you’re the patient. According to a 2017 study, patients with chronic pain are twice as likely to commit suicide.

    It’s not surprising that, from a patient’s perspective, chronic pain and sleep deprivation are emergencies from day one.

    Waiting days, weeks, or months for a diagnosis and treatment leads to the temptation to take matters into your own hands. Unfortunately, one mistake can cost you your life. If necessary, ask for a referral to a pain clinic rather than attempt to manage your pain yourself.

    Read Original Article here>> https://prostatecancernewstoday.com/2018/02/09/prostate-cancer-patients-beware-of-these-4-pain-management-dangers/

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    New tool has ‘tremendous potential’ in predicting prostate cancer risk

    A new genetic tool, the polygenic hazard score, was a “highly significant predictor” of age of onset of aggressive prostate cancer was recently described in BMJ.

    “The good news is we have excellent, curative treatment options (surgery or radiation therapy) when the disease is detected in its early stages,” Tyler Seibert, MD, PhD, of the Center for Multimodal Imaging & Genetics at the University of California at San Diego, told Healio Family Medicine. “However, prostate cancer screening of the whole population has been problematic because of many false positives and overly aggressive treatment of slow-growing forms of the disease.”


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    Men twice as likely to develop oral cancer according to this article. I guess it stands to reason that this would be the case. Since we are always doing stupid things.

    Men are more than twice as likely as women to develop oral cancer*, according to new figures released by Cancer Research UK.

    "Early diagnosis is absolutely key for the best results which is why we’re set on helping dentists and GPs catch oral cancer sooner.” - Dr. Richard Roope
    The latest data shows around 5,300 men are diagnosed with oral cancer every year in the UK compared to around 2,500 women.**

    The data also reveals oral cancer is more often diagnosed in men at a younger age compared with other cancers. Oral cancer is the 11th most common male cancer overall, but among men aged 45 – 59 it is the fourth most common.***

    Oral cancer includes cancers of the mouth, tongue, lips, tonsils and the middle part of the throat (oropharynx).

    Around nine out of 10 oral cancer cases in the UK are linked to preventable causes like smoking, alcohol and contracting human papillomavirus (HPV). The difference between cases in men and women may be due to men indulging more heavily in some of these activities. For example, there are higher smoking rates in men and an estimated 70 percent of male oral and pharyngeal cancers in the UK are linked to tobacco smoking.****

    Cases of oral cancer have been going up in both men and women over the last decade, with rates rising from 10 cases per 100,000 people a year in the mid-2000s, to 13 cases per 100,000 today.***** http://www.cancerresearchuk.org/about-us/cancer-news/press-release/2017-11-29-men-twice-as-likely-to-develop-oral-cancer

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    New kind of MRI scan could bypass the need for a prostate biopsy
    The mpMRI is a godsend for men at risk of prostate cancer, their families, and the doctors who care for them.

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    Prostate Cancer: It’s Not Just an Old Man’s Disease

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    Maybe this guy and all his money will be able to figure out a simple test that will tell men that yes, or no, they have cancer. Interesting at the very least. I wish him good luck!


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    I just seen something on the news about someone making a test for lung cancer that tests your breath. Your breath temp is supposed to be higher if you have lung cancer? This is a new one, never heard that before, but each new test starts with something small like this. Maybe this is a new breakthrough.

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    Interesting article. 4 men per day will die from prostate cancer in Pennsylvania. Most men don't want to get checked. We need to change this, and urge everyone to get checked. I should have gotten checked earlier, my Dad had prostate cancer so I should have been getting checked years ago.