• CAL's Avatar

    4 verus 6 doses of dose dense Taxotere and Cytoxan

    Asked by CAL on Saturday, December 22, 2012

    4 verus 6 doses of dose dense Taxotere and Cytoxan

    Did anyone else get 4 doses of dose dense Taxotere and Cytoxan instead of 6 doses for resected Node positive or high risk node negative, HER2-neg breast cancer? Phase III of the Breast and Bowel cancer clinical trial, NASBP Protocol B-49, is using 6 doses and comparing it to regimes of Adriamycin, Cytoxan, and Taxol or Adriamycin, Cytoxan, Taxotere. If you only had 4 doses, how long ago and what has been your experience?

    BTW, I have had 3 doses so far and will have my 4th next week. I react pretty severely each time to the Taxotere requiring a lot of Benadryl, more IV steroids, and other antihistamines. Each time they have to stop it, give me more drugs, then run it in slower. Last time they ran it over three hours. Also, I have had significant CIPN since the first dose. While I take L-glutamine and Lipoic Acid twice a day and now get cold lazer treatments 1-2 times a week, and walk at least 1-2 miles every day, it persists and only gets slightly better before the next treatment

    4 Answers from the Community

    4 answers
    • nancyjac's Avatar

      I had 6 doses of taxotere and cytoxan for stage 3B inflammatory breast cancer, triple positive. My last treatment was 9 months ago. I developed CIPN about halfway through and still have it. Not sure if it has improved somewhat or I have just gotten use to it.

      almost 5 years ago
    • virginiab's Avatar
      virginiab (Best Answer!)

      I'm not in the trial, but had 4 doses of taxotere and cytoxan for stage II IDC (Her2 neg, hormones pos, 1 node affected). My doses were 3 weeks apart, rather than 4. I had some neuropathy which has persisted so far (3 months since last dose) but is pretty mild.
      I had asked my doctor whether 6 doses were more effective than 4 and she shrugged and said we know that 6 doses of AC are more effective than 4, but we don't have the data yet on TC. She let me decide whether to do 4 or 6. After noting the neuropathy after 3, I decided to stop at 4.

      My radiation oncologist says it takes a long time for the neuropathy to fade....

      Congratulations on almost being finished with your chemo (from a fellow resident of Champaign).

      over 4 years ago
    • Nomadicme's Avatar

      I'd go for the 6. Although sometimes the trials show no benefit, most of the time they do. Two more chemos with someone watching you to control the side effects is ok.

      over 4 years ago
    • leepenn's Avatar

      That's AWESOME that you are walking every day and using glutamine to help with the neuropathy... I keep hearing that couch potatoes suffer more than people who can manage to be active...

      I have no answers for you. I think discussing this with your health care team is critical. I wonder how you might feel if you DON'T do the fifth and sixth cycles. Will that cause you worry? Will you find peace around that? The neuropathy is a big deal, and it is cumulative. So, that should definitely be part of the equation when deciding about whether to do the fifth and sixth doses. So suckeeeee that you are dealing with that.

      I also had a reaction to the taxol - I did fine with just the double benadryl, though... so not nearly so difficult as what you've experienced. I did, however, have the BEST CHEMO NAPS with all that benadryl!

      Well, that's all I have to offer. Make sure you discuss this carefully with your health care team. It's not an easy decision to face...

      over 4 years ago

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