• Another test result I don't understand, haven't been to doctor yet to find out.

    Asked by downbutnotout on Thursday, May 9, 2013

    Another test result I don't understand, haven't been to doctor yet to find out.

    What is a M-spike in urine mean?

    3 Answers from the Community

    • carm's Avatar
      carm

      downbutnotout,
      The fact that you ask these questions is a testament to your investment in your own healthcare. Let me see if I can help you with this one. So patients with myeloma have these monoclonal proliferation of plasma calls in their bone marrow which means that there are many many malignant plasma cells that originate from the same cell. In fact you could say that they have tons of them. These monoclonal plasma cells make immuoglobulins and the immunoglobulins tend to always migrate to a special place called the "gamma region." Because these cells are unique to each person, they will migrate to different places within that region. In Myeloma, immunoglobulin is monoclonal, so on a test using serum electrophosesis (a test that will seperate these blood proteins by size and charge) they will all migrate to the same spot. When this happens you get a big spike and the spike is referred to as an M spike, M for Myeloma or monoclonal and the corresponding protein that spike represents is called an M protein. I hope this helps you a bit. Best of luck to you, Carm RN.

      about 4 years ago
    • downbutnotout's Avatar
      downbutnotout

      Thanks Carm, I just figure that I need to figure out exactly what's going on with me and what the doctors are doing to me. Sometimes they don't seem to give me the full story. Or maybe I'm just paranoid thinking they are holding something back.

      about 4 years ago
    • carm's Avatar
      carm

      downbutnotout,
      I bet you can't imagine how many times I have said that about a patient? I have to pull teeth to get the story out of them. But, I am here and if you need to know anything, I am your official pocket nurse. Take care, Carm.

      about 4 years ago

    Help the community by answering this question:

    Create an account to post your answer Already have an account? Sign in!

    By using WhatNext, you agree to our User Agreement, and Privacy Policy


    Read and answer more multiple myeloma questions.  Also, don't forget to check out our Multiple Myeloma page.