• Anybody with experience with ifosfamide / adriamycin combo? Starting this Wed. 3 straight days of infusion on 21 (or perhaps 28) day cycle.

    Asked by GregA0406 on Sunday, December 2, 2012

    Anybody with experience with ifosfamide / adriamycin combo? Starting this Wed. 3 straight days of infusion on 21 (or perhaps 28) day cycle.

    Bladder cancer that has metastized to the lungs. Tried taxatere - tumors in lungs continued to grow but within "stable" guidelines. Next tried alimta - same results. Went to Sloan for Ph. 2 clinical trial - showed early promise, but latest scan indicates ineffective (40% growth in 8 weeks). After BCG treatment, bladder has been clean for over a year. Tumors now only in lungs. Too many tumors for surgery. Tumors are cavitating. Some hemopthesis daily.

    1 Answer from the Community

    • po18guy's Avatar
      po18guy

      Not exactly, but I did have Adriamycin in two different forms back to back (Doxorubicin and pegylated liposomal Doxorubicin) on a 14 day cycle for eight cycles. But, these two were in combination with Etoposide, Vincristine, Prednisone, Cyclofosfamide, Gemcitabine and Vinblastine. I survived all of that. Unfortunately, so did the lymphoma, but that's another story. The Adriamycin is known to be tough on your heart, although my EKGs are still normal after that double dose. It might also produce some "hand and foot syndrome", in which the palms and bottoms of the feet become reddened, painful, and the skin begins to flake off. The Ifosfamide is considered a tough one when combined with Etoposide and Cisplatin (Carboplatin?) in ICE. But, with just the two of them, it should be doable. Toward the end, you will undoubtedly feel the effects of it, but as they say, the worse you feel, the better the chemo is working.

      over 4 years ago

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