• Anyone have experience with the drug Lenvantinib?

    Asked by debshephard on Tuesday, October 4, 2016

    Anyone have experience with the drug Lenvantinib?

    My husband with be starting a Phase 1 study next week involving this drug and the side effects look a little scary.

    3 Answers from the Community

    • barryboomer's Avatar
      barryboomer

      He is being used as a Guinea Pig....BUT Good Luck!

      over 1 year ago
    • geekling's Avatar
      geekling

      No experience (apologies but I am happy to say because I went through more than enough myownself) but I did look up the side effects:

      https://en.m.wikipedia.org/wiki/Lenvatinib

      Talk to you doctor, of course, but an extract of garlic (Kyolic Garlic liquid extract) can reduce high blood pressure by as much as 75 points. There is nothing in the product but aged garlic extract, water, and some residual alcohol from the extract.

      Have him to please eat lots of garlic in food too.

      There is also a product called "IP6" from plant fiber

      https://www.ncbi.nlm.nih.gov/pubmed/17044765

      https://www.ncbi.nlm.nih.gov/pubmed/14608114

      Again, speak with your doctors. The pill can reduce absorption of iron (not a terrible thing if your iron is from cereal boxes) and calcium (which most of us have plenty of, at least until we get treatments). I took IP6 for years while waiting for a diagnosis (I knew something was not right and begged a plethora doctors to please remove the little growth which the doctors all dismissed as a small wart or hemorrhoid for 13 long years until I developed an affection for organic chocolate ice cream which grew the tumor along with thecrest of me big enough for the myopic doctors to agree to finally remove) so I can assure you it isnt so dangerous but, again, ask your doctor.

      I grow a plant called "moringa oleifera", which I sell as a tea. It contains more vitamins and minerals than you can shake a stick at (A, B of various numbers, folate, C, E, calcium, potassium, iron, beta carrotine, essential fatty acids, and iron). Moringa has even more goodness.

      It also contains quercitin which reduces high blood pressure and has other nice benefits. You also find quercitin in citrus rind..zest .. and pith.

      https://www.ncbi.nlm.nih.gov/pubmed/17951477

      https://www.ncbi.nlm.nih.gov/pubmed/22332099

      You know the drill by now. Ask your doctor.

      Moringa may also lower blood sugar but the studies are few and preliminary.

      http://link.springer.com/article/10.1007%2Fs13197-012-0859-9

      It is also anti inflammatory like turmeric and pomegranates and, like almonds, flaxseed & oats, are anti-inflammatory.

      I sell it as a tea in bags or as a freshly dried powder to add to smoothies and sprinkle on salads:

      www.etsy.com/shop/rawmaven

      There are other side effects listed for lenvatinib. Please write again if your hubby experiences any of them. Enzymes can help ward against loose stool but very little can stand against these powerful drugs in that department.

      Moringa will also help to counter the fatigue.

      If your hubby develops a difficulty eating, I can help. He may not suffer all the side effects. Please write again as soon as you need help, if you do.

      Best wishes.

      over 1 year ago
    • LiveWithCancer's Avatar
      LiveWithCancer (Best Answer!)

      Here's what I know about clinical trials ... or being a guinea pig, as Barry calls participants.

      I got into a trial for nivolumab (as it turns out - i didn't know at the time) when traditional treatments quit working. There were all sorts of potential side effects associated with nivolumab.

      In fact, i am the only person remaining in my trial in the Dallas area. That's been the case for several years. Everyone else has dropped out either because the trial drug was not working for them or because their side effects were too bad.

      But, here's the deal. Your husband will be watched by his oncologist and researcher very closely. I had to have scans every 6 weeks for a couple of years. (They finally moved them to every 3 months about a year ago). All sorts of blood tests will be conducted. If certain side effects that are treatable arise, your husbannd will be given appropriate medications or treatments. At the slightest complaint, my oncologist whisks me off to another specialist, even when i believe it is unnecessary.

      If at any time and for any reason, your husband can quit the trial without repercussions.

      So, when i joined my trial, i thought inwas exactly as Barry says, a guinea pig. And, that was okay with me. I thought my life was nearly over. I never dreamed i would personally benefit from being part of my trial. I joined it purely and simply to help researchers learn for future lung cancer patients. No one was more surprised than me when the trial drug stopped my tumors. And, i personally suffered minimal side effects. The worst has been a malfunctioning thyroid, easily corrected with a cheap little pill each day.

      I hope and pray that your husband won't suffer any side effects and that the trial drug works great for him. If, perchance, there are side effects that break the deal, get out of the trial and seek another treatment plan. Especially with a Phase 1 trial, there's really little way to know what to expect.

      Good luck and please let us know how he is doing.

      over 1 year ago

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