• Anyone have Low Oncotype number, but lymph node positive,ER+, PR+, Her 2neu- and still opt for chemo to take the chances down ? I

    Asked by Giraffe on Thursday, December 27, 2012

    Anyone have Low Oncotype number, but lymph node positive,ER+, PR+, Her 2neu- and still opt for chemo to take the chances down ? I

    I keep thinking that lowering my seedling number is the best possible way to go.

    5 Answers from the Community

    5 answers
    • nancyjac's Avatar

      I can't really answer your question from a personal experience standpoint since I have no oncotype number. However, my personal opinion (and also the opinion of my medical oncologist) is that both patients and some doctors are putting way to much stake in oncotype numbers to determine treatment. The primary factors, particularly with any type of invasive breast cancer should be the size and grade of your cancer, factors that affected the growth of your cancer (HER2, estrogen, progesterone), and the results of PET or other scans that may identify or exclude other areas of possible metastasis. An oncotype assay uses historical and statistical information based on how other people with similar malignant tissue have responded to chemotherapy. And even then that information is categorized by pitting the benefits of chemo against the side effects of chemo, not the risk of recurrence.

      almost 4 years ago
    • Myungclas' Avatar

      I completely agree that it's not that exact a science. That said, even with a low score and no lymph node involvement I couldn't pass up the chemo recommended to lower that number. It just felt like doing everything I could possibly do to keep myself from enduring this journey again. I realize it could still come back, but at least it won't be because I didn't do everything right.

      almost 4 years ago
    • carm's Avatar

      Giraffe, oncotyping in relatively new in the field of oncology. It is the study of the genotype and not the genetics of a disease so it is based on your cancer cell sample and determines if the benefit of chemo is more or less than the risk of the side effects, and whether the chances are greater or less of DCIS or recurrence. As with some other cancers there is the risk of a false diagnosis or pseudodisease. Some cancers do not progress but instead resolve themselves. If your oncotype number is low (below 18) than I believe the rule of oncotyping is a watchful wait and not chemo. If this is what your doc suggests then that is probably what is the better option. As an oncology nurse, it is always that train of thought in patients to want to be aggressive and treat right away. Sometimes doing that can stunt your bodys effort to correct the mutation on its own. Treating early at times starts the chemo clock. From your first treatment on you assault cells that one day might not be able to overcome the effect of chemo. When that day comes, the clock stops and the option of chemo comes off the tartble. Sometimes its good to have an oncologist who does not have an itchy trigger finger. Oncotyping is not cheap and the info can be valuable. It would be a waste not to follow the resulting recommendation just because tradition dictates you should react to anything. Not all cancer diagnoses prove fatal. Best of luck, Carm.

      almost 4 years ago
    • Nonnie917's Avatar

      I have never heard of this oncotype number stuff. Is this something that I should be worried about myself? I am pluses all the way down the line on the HER2, PR and ER, but did not involve the lymph nodes at all, and my oncologist never said a word to me about this. Are my chances of getting cancer again, because of this typing, stronger than I thought they would be because they got it all when I had my double mastectomy? Now I am scared and don't know what to do. I didn't have to have chemo or radio and now I am beginning to wonder if that should have been done???? Please help me understand this before I call my oncologist.

      almost 4 years ago
    • Tami's Avatar

      I believe in order to have the Oncotype DX test you need to have the right qualifications. By that I mean you have to be newly diagnosed and ER or/and PR positive. I had the Oncotype DX test in 2008. I don't mean to scare anyone but I tested low (17) with no lymph node involvement. My doctor did not recommend chemo. Two years later I had a recurrence at which time it was discovered the cancer had spread to my bones. I ended up switching Oncologist, my new doctor explained I had a 7% chance for a recurrence based on the Oncotype test. I agree doctors put way to much stake in oncotype numbers to determine treatment.

      almost 4 years ago

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