• Anyone taking Zytiga to treat stage IV prostate cancer?

    Asked by Ginny2 on Sunday, August 4, 2013

    Anyone taking Zytiga to treat stage IV prostate cancer?

    I'm the caregiver for my husband of 52 years. The chemo treatments stopped working and his PSA started rising dramatically. He started taking the drug Zytiga ten days ago and I'm wondering if anyone can compare side effects they've experienced that may be related to Zytiga. He was extremely fatigued before starting it and two days after starting he had to have two units of blood transfused. A couple days after that he had very low blood pressure and needed fluids infused. This may not be from the Zytiga but I want to know if anyone else has experienced anything similar. Yesterday was his best day in a month but today the fatigue is back.

    Any feedback would be greatly appreciated! Thanks,

    8 Answers from the Community

    8 answers
    • Coachm214's Avatar

      I am also a caregiver to my husband of 49 years. He also has stage IV prostate cancer diagnosed 2 years ago. He is getting Lupron shots every 3 months and Xgevia monthly. In April they started him on Zytiga. He took it for 3 months with no side effects. He stopped because he needed radiation for a tumor on his spine. The radiation worked, he is pain free but has not resumed the Zytiga. We are now discussing chemo options.

      over 4 years ago
    • MichaelV's Avatar

      I started taking Zytiga when my PSA started going up and up even though I was on Lupron every 3 months. I was on it for about 15 months and I had no side effects at all. During that time I also tried Provenge and had plenty of side effects with that treatment but it did not lover my PSA at all. While on Zytiga my PSA dropped between 6 and 8 points a month and then all of a sudden started to rise and the Zytiga seemed to have lost it's affect.
      I might suggest that you pay close attention to his diet. What we put into our bodies has a great affect on how we handle any disease. I have many books on the subject and one that I found very helpful can be found on Amazon and here is the link to Never Fear Cancer Again:


      If you read through my journey you will find I have been through a lot and I am happy to share information with anyone who is in a similar situation in the hopes they will avoid some of the same mistakes that I have made.

      It is important to note that everyone is different and that is very true when it comes to disease and the drugs used to handle the disease. I did three treatments of Taxotere and it XXX never killed where friends of mine had minimal reactions to the chemo.

      There are 1000's of use with this insidious disease and we can help each other to hold steady, believe in your power to heal yourself and keep a positive attitude, ALWAYS.

      Let me know if I can be of help,


      over 4 years ago
    • Marty's Avatar

      Hi Ginny:
      I started taking Zytiga as part of a clinical trial. After 1 month my liver engymes were 5 times normal. I waited for the liver engymes to go to normal and they reduced my dosage and had me go on weekly blood tests. Liver enzymes went back up in a week. Stop Zytiga and wait, rastart on an even lower dosage and the same thing happened. Now I am in Xtandi. So, I donth think I ever took it long enough to know about other possible side effects.

      over 4 years ago
    • fishinfreak's Avatar

      when I first started taking zytiga I was still getting side effects from chemo. my psa kept rising for about 2 months then dropped to 0.2 and stayed there for about 6months . during that period I was feeling very good and was doing things I hadn't done in a couple of years. I am now back on a different chemo treatment. (I hope this treatment works for quite a while

      over 4 years ago
    • Jake's Avatar

      Ginny2, I started Zytiga 6 mos ago and I have responded very well to the drug. My doctors said it would take a while to work, which it did. All of us are different, but I can say without a doubt that it helped me. Wish you both well.

      over 4 years ago
    • MichaelV's Avatar

      I took Zytiga for 15 months before it stopped working for me. I also took 5mg of Prednisone in the morning and at night. I had no side effects at all. I never had any fatigue that I could associate with Zytiga. Hope this helps. I also started a blood pressure medication as it can increase ones blood pressure.

      over 4 years ago
    • jackc's Avatar

      I started taking Zytiga along with Elegard 6 month shots when PSA leveled off about 6 months ago, No side effects and PSA continued downward Also eating vegetarian diet. everything going well except now developing pain in right femur. pretty much same program as MichaelV.

      Any suggestions? JackC

      about 4 years ago
    • bisoux's Avatar

      My husband was diagnosed with Stage 4 prostate cancer (mets to the bones) in March of 2012. He quickly got a point where he was in excruciating pain and couldn't walk. He was on oxycodone and morphine and we were expecting the worse. But he started taking Zytiga in March of 2013 and it is still working today (June of 2014). His PSA dropped pretty quickly down to 2 and even though it has bounced just a little bit, it has stayed in that general area. His side effects have been fatigue and nausea. I hope this lasts for a very long time. God bless all of you!

      almost 4 years ago

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