Hi Deb. I have only been on anastrozole (the generic for Arimidex) for a month, so I can't answer your questions from personal experience as a long term user. But I did ask all of these questions of both my oncologist and other cancer survivors who have used Arimidex long term and am happy to share those answers with you.
Some have suffered joint/bone pain, others have not. So started having pain almost immediately, other not until 3-