• Aromatase Inhibitor SE and Osteoarthritis

    Asked by nancyjac on Friday, September 14, 2012

    Aromatase Inhibitor SE and Osteoarthritis

    So I have a bit of a catch 22. I have osteoarthritis in one knee. Cortisone injections work well but not long enough and my orthopedist does not want to give me a shot ever 2 months due to the cumulative side effects of long term steroid use. My oncologist wants me to do weight bearing exercise to maintain bone density. So basically I have to suck it up in terms of the knee pain, or take NSAIDS on a long term basis, which have their own side effects. I am not a candidate for knee replacement at this point.

    So I'm interested in any body else on an AI who also has osteoarthritis. What do you take for the arthritis that has been approved by your oncologist in terms of interaction with you AI? I am already taking low doses of naproxin and considering adding a capsaicin and/or glucosamine/chondroitin/msm supplement.

    6 Answers from the Community

    6 answers
    • lynn1950's Avatar

      Hi. I have osteoarthritis and have been on Arimidex for almost 4 years now. My arthritis is mostly in my hands, shoulders, and back. I take 600mg. of ibuprofen as needed. It helps with the stiffness and joint pain so that I can stay active. I guess there are SEs to anything you take...

      over 8 years ago
    • ruthieq's Avatar

      I took AIs for 5 yrs with Rheumatoid arthritis, and I can understand where you're coming from. One way to exercise and use your joints but with less pain is water aerobics(preferably for arthritis sufferers). This has helped me in the past and helps keep the joints limber without too much stress on them. AI SEs "suck" as they say especially for those of us with compromised joints. Sometimes the Y will have classes, or if you have a large rehab facility in your area, they sometimes will have a pool and offer classes as well, but you will need an RX.As far as the pain goes, Nsaids 600mg-800mg(Rx) from your doc of Ibuprofen or taking Aleve, (Naprosyn) will help. I wasn't aware that NSAIDs interact with AIs. Your ideas for the other supplements may also work well for you. :)

      over 8 years ago
    • Laurie's Avatar

      I wasn't aware that nsaids had any bad interaction with AIs. I take naproxen not infrequently. My primary has a cow, tho because doesn't want gastric ulcers from chronic nsaids (well, neither do *I*, but it was never a problem before, so..........). She also doesn't want me on steroids (I have asthma and occasionally have to take). So, geez, what do you want me to do????? You could try glucosamine/ chondroitin with or without MSM and see if it helps reduce your naproxen need. Are you a candidate for hyaluronic acid injection in the knee?? I tried the capsacin cream. it didn't seem to do anything. Then I took a shower. Holy crap! Warm/ hot water on it burns!

      over 8 years ago
    • nancyjac's Avatar

      I don't think anybody has said that NSAIDS interact with AIs, just that NSAIDS have side effects of their own. I've started taking Osteo Biflex. No sure if it helping yet. Sometimes my knee feels ok but other times (especially at night) it hurts pretty bad. Haven't figured out if it is the naproxen, the osteo biflex, or just keeping it moving that is helping or if it is some combo of all three. I've taking the naproxen and osteo biplex at night hoping to ease the pain at night, but maybe I am taking it to late for it to kick in at night, so might back it up some and see if that helps.

      over 8 years ago
    • workit's Avatar


      Effect of exercise on bone structural traits, physical
      performance and body composition in breast cancer patients -
      A 12-month RCT


      I haven't read this yet, but you might find references within the article for AI and Osteoarthritis. Table 1 lists AI's so there might be some text comment regarding them.

      over 8 years ago
    • nancyjac's Avatar

      I'm generally not a big fan of home remedies and wive's tales, but a couple of weeks ago, a friend of mine told me that both she and her mom have been taking apple cider vinegar that helps significantly with arthritis pain. Since nothing else had been working well and I didn't see where it could do any harm, I decided to give it a try. Much to my surprise, it has helped considerable. It's not an instant wonder cure by any means, but after two weeks of taking it, my knee pain is noticeably less than with just the NSAIDS and I am able to at least get back to some level of exercise, which I know will eventually help it even more.

      I also happened to have my annual physical with my PCP a couple of days ago and she told me that she herself takes the Synvisc injections for her own knee arthritis and recommended them highly to me. I hadn't tried those because the steroid injection didn't last very long and my orthopedist (who my PCP says is the best in the area) said a lot of his patients who didn't get long term relief from the steroids had the same issue with the Synvisc. But my PCP said the steroid shots do nothing for her arthritis pain but the Synvisc gives her signifcant relief for 8-9 months before she needs another set of injections, so I think I am going to give it a try.

      over 8 years ago

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