• BRAC Positive - Any guys out there with the same?

    Asked by CrazyHarry on Saturday, April 13, 2013

    BRAC Positive - Any guys out there with the same?

    Just found that I have the BRAC mutation. Of course followed that up with some internet surfing. Found out that I'm now open to getting a wide range of different cancers and possibly the rectal cancer I got was from this.

    Any guys out there with this mutation and having any extra issues?

    6 Answers from the Community

    6 answers
    • carm's Avatar

      A BRAF mutation is a mutation of an oncogene. It is a point mutation in the DNA chain most often seen in the 600 codon where the amino acid, glutamic acid (E) is substituted for valine (V) so it is represented like this: E600V mutation. Codons are nucleotides (base pairs) in sequences of 3 and many are in a DNA chain. It is a common mutation in cancer that occurs on the 7th chromosome. It is good that you learn these mutations and where and how they occur. If nothing else, this knowledge validates that this error is indeed the product of biology. Oncogenes are one of two of the most common genes that cause cancer, tumor suppressor genes are another. By this description, you can see just how long a DNA chain can be. Because this is a common mutation, there are many therapies out there to combat it. Best of luck to you, Carm RN.

      over 4 years ago
    • carm's Avatar

      P.S: Forgot to mention that you probably mean BRAF not BRAC. BRAC is referred to as BRCA, the breast cancer gene.

      over 4 years ago
    • CrazyHarry's Avatar


      I do mean the BRCA/BRAC.

      My mother 41, grandmother 36, great aunt 35 all died very young from breast cancer.

      over 4 years ago
    • CAS1's Avatar

      In simple terms
      An Oncogene is a driver mutation..This my cause cancer
      Then there are tumor supressors..when turned off they let cancers grow.

      In a few earlier posts I talked about the new ideas ( 10Years old) in thinking that it really does not matter where the tumor starts in the body. What matters are the mutations and the cancers personality.

      I am in the same situation. Grandparents died of cancer, both parents and my sister at just 58 and now me. I have an EGFR mutation that we beleive was present in my Father and sisters cancers as well. I suggest you see a genetic specialist to dicuss what all of this means for you.

      over 4 years ago
    • leepenn's Avatar

      hey crazy harry - yes - i do have a friend who's a dude who's brca positive... he had a double mastectomy and crazy chemo... very similar to what i had to do. he's doing well...

      one thing he plans to do is have his children tested for the mutation - so that they KNOW. are you a father? if yes, it's definitely something to think about, especially in light of your birth family history!

      drag - isn't it? as far as i know, i am not brca positive... i wasn't tested since i didn't seem to have any birth family history pointing me in that direction and since i am not a birth mom (i'm a mom by adoption)....

      good luck.

      over 4 years ago
    • carm's Avatar

      If you meant BRCA, then it is indeed possible. As a matter of fact the BRCA gene is associated with pancreatic cancer as well. I have patients with moms and aunts with breast and ovarian cancers and sons and uncles with pancreatic cancer. I sent you some info off line to help you understand the genetics of these mutations, Carm RN.

      over 4 years ago

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