• Can Lupron injections cause dramatic mood swings?

    Asked by HotRodTodd on Wednesday, January 30, 2013

    Can Lupron injections cause dramatic mood swings?

    4 Answers from the Community

    4 answers
    • carm's Avatar

      Lupron is a LHRH or a leutinizing hormone-releasing hormone that the body releases prior to releasing progesterone. Having administered it as a nurse, I have seen many similar side effects that you see when you manipulate estrogen like mood swings, hot flashes, and so.etimes gynomastica. Your oncologist should have explained this prior to administering the injection. Best of luck to you, Carm.

      over 3 years ago
    • notwillie's Avatar

      From our experience, Lupron injections are used in conjunction with other drugs to block the production of testosterone, the hormone upon which the Prostate cancer feeds. Therefore, less testosterone creates similar side effects to the female menopause. Hot flashes, mood swings (although not dramatic) night sweats, and some physiological changes are common. In my husband's case they have not been overly troubling and certainly worth it, in light of the alternative.

      over 3 years ago
    • Ross' Avatar

      I have been on Lupron for almost 3 years now. The combination of Lupron & Casadex have caused hot flashes & night sweats. I now take Megace to help control the hot flashes and it helps some. I have generally not had mood swings. I do experience some occasional depression and that seems to be less now. All in all, my experience with these drugs ( and now Xgeva has been added to my drug list) has been good as long as you accept ed as a consequence. Best wishes as you seek treatment. A survivor, Ross

      over 3 years ago
    • mgm48's Avatar

      They said it all - no testosterone means your hormones have changed. I sympathize with the women and menopause. But I do get some mood swings and I have been on Zoladex (a Lupron alternative) for 18 months now. I no longer get the hot flashes, but mood swings do occur (kinda like my wife's months before menopause), gynomastica (man boobs) not huge but some gals I know are jealous, and some stomach upset. Given a choice of having the cancer grow faster or deal with the foregoing, I'll deal with it.

      Keep it positive and smile :)

      over 3 years ago

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