I don't know that this is specifically related to prostate cancer, or any type of cancer for that matter. I get up at least twice every night, sometimes more, to urinate and have been for years. I'm able to go right back to sleep so it isn't a problem for me. I think as we get older, our bladders get a bit weaker. We also need to take in more fluids to stay well hydrated and that is going to translate to more frequent urination.
The blood in his urine is another matter entirely and needs to be checked out.