• Effects of propranolol on immunotherapy for melanoma and other cancer Should?

    Asked by Lundmusik on Tuesday, April 24, 2018

    Effects of propranolol on immunotherapy for melanoma and other cancer Should?

    Has anyone heard of pan-beta blockers such as propranolol? I discovered a recent Penn State study showed remarkable impact of combining propranolol with immunotherapy for melanoma. There is now a trial established for combining propranolol with Keytruda. The study showed a 70% 5 year survival for stage 3 and 4 melanoma when a pan beta blocker was combined, versus only 27% when either no beta blocker or a non-pan beta blocker was used.

    When presented all of this to my oncologist and primary physician, they agreed to let me pair propranolol and Opdivo for this next year (given no adverse side effects of course). There are some reported benefits for other cancers that I haven’t looked into yet.

    The url for this is as follows:

    https://www.medscape.com/viewarticle/891251

    8 Answers from the Community

    8 answers
    • Lundmusik's Avatar
      Lundmusik

      My primary physician was skeptical until she had reviewed the research and the standards for the trial. I’m not on the tria because I don’t yet have unresectable disease, but newly approved Opdivo for stage 3, together with the already allowed and researched pan beta blockers, convinced her and my oncologist that, with appropriate supervision, it was worth our own supervised trial. I am on 40 mil twice a day, but only if my starting heart rate is above 60 bpm, and upper blood pressure reading no less than 100. I’m already on amlodipine, valsartan and a diuretic for blood pressure. My history bpm has been low in recent
      Years because of my workout regimens ( average 64 bpm). It’s worth noting that a supervising physician on the Penn state study is already ensuring that his cancer patients who are already on beta blockers are now on pan beta blockers, specifically propranolol. Please read the url that’s part of my question post.

      I’m a 3D melanoma — relatively new category that carries the worst possible prognosis short of stage 4, which is still relatively a death sentence for a significant percentage of patients, even with new immunotherapy. I’m not willing to wait until I find out in five years that I’m part of the 75% that didn’t make it without this new therapy.

      almost 2 years ago
    • Terri's Avatar
      Terri

      Great information, Thank you! I have Stage 4 and they put me on it and it made me feel awful. I may reconsider my decision not to take it.

      almost 2 years ago
    • Lundmusik's Avatar
      Lundmusik

      Terri

      What did they put you on that made you sick. Are you on anything now?

      Chuck

      almost 2 years ago

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