• Estrogen blocking drug therapy

    Asked by HappyJoe on Thursday, January 17, 2019

    Estrogen blocking drug therapy

    I am looking for feedback on the pros and cons of going forward with the estrogen blocking drug therapy my oncologist is recommendind

    7 Answers from the Community

    7 answers
    • cllinda's Avatar

      It depends on the kind that is given. Some seem to have more side effects than others. I have been on anastrozole (generic for Arimidex) for six years now and no problems so far. I was told to go on it for five years and then my doctor told me I should take another five years. It is not only supposed to keep breast cancer away, but other cancers as well. So I am continuing this medication.

      6 months ago
    • lynn1950's Avatar

      I just took my last dose of Arimidex on Oct.31 - ten years of Arimidex, joint pain, osteoporosis, depression, weight gain...but no sign of cancer. It was worth it.

      What other cancers does Arimidex prevent, cllinda?

      6 months ago
    • cllinda's Avatar

      When I think about it, he just said other cancers and didn't get into specifics.

      6 months ago
    • EJKIRBY's Avatar

      I have been on Arimidex for 6 years with no noticeable side effects. Or maybe there are side effects but I don't know if they are from the Arimidex or the natural aches and pains from the aging process

      6 months ago
    • ChicagoSandy's Avatar

      IIRC, other estrogen-sensitive cancers may include ovarian and endometrial.

      Cons of aromatase inhibitors are the side effects (most of which mimic menopause because they are all caused by estrogen deprivation). Pros are that the treatment is life-extending; and for HER2- women with early (Stage I or II) node-negative breast cancers, so life-extending as to be, for all intents and purposes, curative.

      I've been on the AI letrozole (aka Femara) for 3+ years (at least 2 more to go). My side effects have been a slight increase in preexisting osteoarthritis joint soreness, a trigger thumb & finger (which spontaneously resolved), thinning hair (but not to the point of bald spots), drier skin (but mine had been oily), night sweats (ceiling fan &/or A/C takes care of that, occasional insomnia (eased by taking CBD) and lowered metabolism resulting in moderate weight gain (I was already obese). I don't think it's caused me any cognitive impairment beyond that of normal aging--certainly nothing like "chemo-brain." I was osteopenic before treatment, but Prolia shots and calcium/magnesium/D3/K2 supplementation actually caused a slight improvement in bone density!

      In short, there are workarounds for nearly every side effect.

      6 months ago
    • mofields' Avatar

      I have also been on anastrozole for going on 6 years. I have had few side effects (mostly weight gain and some early morning joint pain (but I'm also near 60). I have breast cancer (nearly 5 years out now) and this was prescribed for my estrogen positive type. If it keeps the cancer from coming back I'll take this little, white pill. When I saw my oncologist in November he recommended to continue the next 5 years (the recommended time is 10 years) since I am handling the pill well.

      6 months ago
    • Annebal's Avatar

      I began on tamoxifen but started bleeding and had terrible joint pain so I was switched to letrozole. In the meantime, because of the bleeding and post-childbaring time I had a complete hysterectomy.

      I saw my oncologist for the last quarterly visit 2 months ago!! I'm off of all things cancer but now I'm experiencing heavy discharge. Any insight?

      6 months ago

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