• Estrogen blocking drug therapy

    Asked by HappyJoe on Thursday, January 17, 2019

    Estrogen blocking drug therapy

    I am looking for feedback on the pros and cons of going forward with the estrogen blocking drug therapy my oncologist is recommendind

    7 Answers from the Community

    7 answers
    • ChicagoSandy's Avatar

      IIRC, other estrogen-sensitive cancers may include ovarian and endometrial.

      Cons of aromatase inhibitors are the side effects (most of which mimic menopause because they are all caused by estrogen deprivation). Pros are that the treatment is life-extending; and for HER2- women with early (Stage I or II) node-negative breast cancers, so life-extending as to be, for all intents and purposes, curative.

      I've been on the AI letrozole (aka Femara) for 3+ years (at least 2 more to go). My side effects have been a slight increase in preexisting osteoarthritis joint soreness, a trigger thumb & finger (which spontaneously resolved), thinning hair (but not to the point of bald spots), drier skin (but mine had been oily), night sweats (ceiling fan &/or A/C takes care of that, occasional insomnia (eased by taking CBD) and lowered metabolism resulting in moderate weight gain (I was already obese). I don't think it's caused me any cognitive impairment beyond that of normal aging--certainly nothing like "chemo-brain." I was osteopenic before treatment, but Prolia shots and calcium/magnesium/D3/K2 supplementation actually caused a slight improvement in bone density!

      In short, there are workarounds for nearly every side effect.

      6 months ago
    • mofields' Avatar

      I have also been on anastrozole for going on 6 years. I have had few side effects (mostly weight gain and some early morning joint pain (but I'm also near 60). I have breast cancer (nearly 5 years out now) and this was prescribed for my estrogen positive type. If it keeps the cancer from coming back I'll take this little, white pill. When I saw my oncologist in November he recommended to continue the next 5 years (the recommended time is 10 years) since I am handling the pill well.

      6 months ago
    • Annebal's Avatar

      I began on tamoxifen but started bleeding and had terrible joint pain so I was switched to letrozole. In the meantime, because of the bleeding and post-childbaring time I had a complete hysterectomy.

      I saw my oncologist for the last quarterly visit 2 months ago!! I'm off of all things cancer but now I'm experiencing heavy discharge. Any insight?

      6 months ago

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