• Even in a situation in wich PSA is increasing, can be considered a good news if this increse is getting more slow ?

    Asked by Poliana on Sunday, January 13, 2013

    Even in a situation in wich PSA is increasing, can be considered a good news if this increse is getting more slow ?

    This question is about my dad´s case. He is totally assymptomatic (No pains, minimal side effects from meds, etc.), he has two bone lesions (L1 and T7) and has taking hormonetherapy, but PSA is growing. In sep/12 it was 22, in dec/12 was 70, and january (last friday) 109. As I´m good with math and statistics I made some comparisons among the PSA numbers, took into account the number of weeks elapsed among each PSA exam and the relative rate (Percentages) of growth. My conclusion was that despite the growth in absolute numbers the relative growth rate is decreasing. Between august and september grew on average 22% per week, between september and december 20% per week and between december and january 11% per week, wich means a reduction of almost 45% in the growth rate. Does it make sense ? Am I right in my reasoning that this is good or not has nothing to do with the possibility of some reduction in growth rate ?

    3 Answers from the Community

    • nancyjac's Avatar

      The rate of increase in PSA over time is called velocity or PSAV. A low rate of increase over time is good, but generally the standard for that is an increase of less than 4 over the course of a year. Many things can affect PSA values temporarily at any given time, so an average percent change per week is probably of little value.

      almost 4 years ago
    • notwillie's Avatar

      From our experience, it is likely your dad's body is beginning to resist the particular medications he is on. DO not despair. There are others out there and also new drugs coming to market every day. Did they stage your dad's cancer? My husband is in stage IV and has no pain. They tell me it is not uncommon. Hoping for a good report on your dad sometime soon.

      almost 4 years ago
    • mgm48's Avatar

      Nancyjac and notwillie are correct. As the PSA goes up it is just an indication that there is some activity. There are several things in your future. I'm currently recovering from a side effect of the trial drug I've been on. So I'm on hold - no drugs probably for a couple weeks. In this disease I've found that a week is nothing, a month is not much more and we fight on. Be patient and yes the lower velocity is good but don't get too caught up in it.

      Keep it positive and smile :)

      almost 4 years ago

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