Tons of us have had Folfox. I worked during it, but as I own the business, I could take short days or naps as needed. But there were days I went into work wearing the chemo pump.
You'll see how you feel. It depends on your level of fatigue and side effects. No two people react the same to this treatment; for many it is very difficult, for others, it is merely a nuisance.
Good luck with everything!