I don't have experience with either CTCA or Dana-Farber, but I might be able to provide a little insight. CTCA is a for-profit chain of treatment centers with the claimed goal of providing advanced cancer treatment. I don't know how well they attain that goal. From what little I can gather, they offer average to good treatment--maybe excellent.
Dana-Farber is in an entirely different category. They are one of the best cancer research centers in the country. There are only a few places that equal (I don't pick "bests" in this sort of thing) their reputation--places like MD Anderson in Houston, The Cleveland Clinic, the Mayo Clinic, etc. I know there are others but I'll stop there. These are the places where the major breakthroughs happen. Places like CTCA use their research. If you need, or want, the very latest in treatments or wish to engage in clinical trials of drugs that aren't generally available, then these are the places you go to.
For most of us, the treatment at our local hospitals and treatment centers is good and doesn't require us to travel to Boston, etc. The personal attention we get can be significantly greater than at one of the major centers. We get the same drugs--except for the experimental stuff. We might keep an ear to the ground for news coming from the major centers. Dana-Farber's Bing Center for WM announced a major breakthrough in understanding WM last year which offers a real hope for a cure of my, currently, incurable cancer. The Mayo Clinic is conducting clinical trials of an alternative to Rituxan which I might need in a few years.