• Has anyone who's ER+ had an OB/GYN or Oncologist who let them use topical estrogen while taking Tamoxifen or an Aromatase inhibitor?

    Asked by AlizaMLS on Thursday, February 21, 2013

    Has anyone who's ER+ had an OB/GYN or Oncologist who let them use topical estrogen while taking Tamoxifen or an Aromatase inhibitor?

    I'm dealing with the usual symptoms of impending (natural) menopause including hot flashes and vaginal dryness, but I'm ER+, so I know I'll probably be going on some kind of hormomal therapy (if I can stand it [it's hard for me with the usual menopausal symptoms, but I've got Lupus as well]) and sex has become, well, extraordinarily uncomfortable would be putting it mildly. I've gone back to the "Old" K-Y jelly...;) (Never mind, "Yours and Mine"). I had an Oncotype test that was fantastic (i.e., I don't need chemotherapy because I've got little chance of a reoccurrence), but my ob/gyn wanted to run a genetic test on me before she really felt comfortable prescribing topical Estrogen. What's with that? Has anyone else had that experience? Is there anyone in the medical community on the site that can explain that? Thanks much!

    4 Answers from the Community

    4 answers
    • carm's Avatar
      carm (Best Answer!)

      Aliza, hello I hope you are well. Let me try and explain your docs rationale. I understand that you are menipausal and the loss of estrogen can be extremely uncomfortable especially in the vaginal vault because it causes vaginal dryness. There are actually 3 types of estrogen that circulate in the body. There is estradoil, estrone, and estroil. The weaker are the last two and topical estrogen therapy is called exogenous estrogen because it is local and does not circulate systemically. It replaces the loss of hormone in the vaginal vault that causes vaginal dryness without getting into your system. It is the weakened form of estrogen and most of these products are estrogenic in that they are synthetic that only mimic estrogen. These topical steroids are often prescribed with low risk and if used as directed, are safe. I hope this helps. Best of luck to you, CarmRN.

      over 3 years ago
    • pll's Avatar

      yes, I've used one for years and I was ER+ as well. My gyno & oncologist both feel the low dose, topical use is minimal risk. btw, the one I use is a tablet suppository. much less messy than using a tube and applicator. it costs a little more on my pharmacy co-pay as it is a brand name w/ no generic equivalent. To me, it is worth the add'l cost. good luck.

      over 3 years ago
    • Netsy's Avatar

      I was told to use Replens (Walmart) helps replenish vaginal moisture and is estrogen free. One application every 3 days. I was told k-y would not work well enough. Ask your Doctor's it is over the counter.

      over 3 years ago
    • karen1956's Avatar

      My oncologist Rx the e-string for me. He feels that the amount of estrogen released by the e-string is not enough to be contra-indicated for ER+ women. My gyn told me to go to the "XXX" rated stores for lubricants as he feels that they work better than KY jelly.

      over 3 years ago

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