• How creditable do you think the CA125 test is?

    Asked by Beaner54 on Saturday, September 8, 2012

    How creditable do you think the CA125 test is?

    3 Answers from the Community

    • Cindy's Avatar

      I've heard conflicting information. Websites say there are a lot of false positives and negatives associated with the test which is why it's not routinely used for detecting ovarian cancer early for most healthy women with no personal or family history of the disease. I would say that the CA125 test is more of an indicator rather than a diagnostic tool. Other tests would be needed to confirm any suspicions. My doctor strongly believes in having me get a CA125 test regularly (initially monthly, now every 2 months). My CA125 level was 430 when I was first diagnosed with ovarian cancer. Normal should be below 36. After my cancer surgery, it went down to 43. After 6 chemo treatments spaced 3 weeks apart, it got below 10. My doctor said that because my numbers went down that low, that was an indicator that the chemotherapy worked and lessens the chances for a reoccurrence. It started to go up a little a few months after the treatments but has now held steady around 10. My doctor said he looks for trends. If my CA 125 test results would have continued to increase, it would be an indication of my cancer coming back and he would order more tests to determine where.

      about 4 years ago
    • nancyjac's Avatar

      The test itself is quite reliable at measuring the concentration of the CA-125 protein. However, that in an of itself is not particularly useful for diagnosing cancer, since many other things can cause an elevated concentration of CA-125. The opposite is also true. Elevated concentrations of CA-125 do not always occur with cancer this is not driven by the CA-125 protein. This test is useful in conjunction with other diagnostic tools such as biopsies, sonograms, etc. and is often used to a monitoring tool to look for any trending in results post active treatment that might be indicative of a cancer recurrence that would need additional testing to confirm.

      about 4 years ago
    • debrajo9's Avatar

      I agree with the others. CA-125 is just an indicator,not a for sure and it only works well if no other health issues are present. At best, I think CA-125 is 50/50.

      about 4 years ago

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