• How effective is Tarceva for Stage IV metastatic Lung Cancer with Kras mutation ?

    Asked by kos56 on Thursday, May 16, 2013

    How effective is Tarceva for Stage IV metastatic Lung Cancer with Kras mutation ?

    My husband's lung cancer has metastasized to his two adrenal glands, a lymph node in his chest and now to a rare excruciating place, the mandible (jawbone) in his face. He had one chemo session on march 7, 2013 but reacted with such extreme vomiting that he ended up hospitalized for 4 days. Then the face pain began to developed and finally presented in imaging after about six weeks. Now they are starting him on 15 short radiation treatments and Tarceva as he is in too much pain to tolerate chemo. Any thoughts or advice? Thank you.

    3 Answers from the Community

    • CAS1's Avatar

      Tarceva has the best chance of working with an EGFR Mutation. But it can also work without in some people. There is a great deal of work being done on the Kras mutation because its so common in L/C . There are certain chemos that are more effective with KRAS.
      The side effects of Tarceva are usually mild and to get it with Radiation gives the best outcome. If he responds to the Tarceva it can last for quite a while and there are numerous drugs in pipeline to counteract the resistance that eventually builds up in Tarceva.
      Make sure you are getting treatment at a top line Lung cancer expert facility.

      Also ask about clinical trials. So much is in the pipeline that holds real promise even for advance stage. I am posting some data now.

      almost 8 years ago
    • kos56's Avatar

      Cas 1 Thank you You are a treasure on this site. God bless you. Karen

      almost 8 years ago
    • CAS1's Avatar

      Thank you Kos,
      We are going to hear a lot of data coming up after my 31st when the American Society of Clinical Oncology starts their meeting in Chicago. KRAS is a hot topic and lots of research being done because its common in multiple cancer lines too.
      That new PDL-1 is really hot..22% response in LC..thats one its own without chemo.

      Hold on there is real hope.

      almost 8 years ago

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