• How long did chemo last?

    Asked by katiecb on Thursday, June 13, 2013

    How long did chemo last?

    My mom was diagnosed with Stage 4 pancreatic cancer in October, she is getting intensive rounds of chemo every 3 weeks. 2 hours during first round, 1 hour and 45 minutes in the second round and a 46 hour pump she takes home. She asked her doctor today what the plan was, and he said that chemo is working, if it stops, they could switch chemo, is this her quality of life? Is this her forever? Or are their other options? She has second opinion from another doctor in July. Any ideas/good questions to ask doctors?

    4 Answers from the Community

    4 answers
    • pancrease54's Avatar

      Sounds normal to me. Doctors many times discover that a second or third round of lesser known kinds of chemo get great results. I am certain your Mom has been told "Everybody is different" I did 6 months of 24/7 3 weeks on/one week off.(5FU) They tried to kill me but it worked. 2 days before the end of my last month I called my onc to tell him I was near death. Doc said to lay the phone down and pull the needle out of the port in my chest. When I picked back up Doc said it was good I called, I could have spent Christmas in the hospital. Not an exact science.
      Best of luck, sounds good!

      about 8 years ago
    • JMS's Avatar

      Dear katiecb - your question is interesting to me because a coupleof days ago, I put one out there that's very similar. So, at least let me tell you what my doctors have said to me about your question. I don't know what your Mom is taking, but I'm now on Folfirinox (which is a combination of 4 chemo drugs). It's much stronger than the Gemzar I was previously on and takes much longer for the infusions. I now have 6+ hours of infusions at the hospital every other week, then go home with a slow-drip bag for the next 48 hours. I'm much more dizzy, exhausted, and feel considerably more nausea than previously. Also have issues with putting food or drink in my mouth (very painful, especially cold things) and cannot pick up or hold anything cold as my fingers begin to hurt as though I'm being stabbed.
      On the issue of how long the treatment period will last, my local doctor indicated I'd stay on this until the drugs didn't work or I could no longer tolerate them, whichever comes first. He might then switch me to a combination of Abraxane and Gemzar as a trial. My Johns Hopkins doctor has indicated much the same thing, with one exception: if my tumor markers come way down after the first 6 months, and my CT scan is clear, she'd consider taking me off chemo for a while to give me a chance to recoup., Then if the numbers start to go back up, she'd start me up again for another 6 months. There are no clinical studies on this - it appears. Also, since use of Folfirinox is fairly new for pancreatic cancer patients, the longest anyone has been using it is around 2 years, so this too does not provide much useful information. You might want to ask the second opinion doctor about on/off strategies and if he/she knows of any studies that indicate how long a patient might be able to put up with this chemo regimen (and what is the longest time his/her patient has been able to remain on the drug)?
      Hope this helps a bit at least. JMS

      about 8 years ago
    • JMS's Avatar

      katiecb - let me at least give you the information I do have. I don't know which chemo drug your mom is on (Folfirinox or the Abraxane/Gemzar combination), but I can share with you what I learned at the Pancreatic Cancer Network advocacy day events held recently in Washington DC. There was a break-out session focused on new treatments and developments. The doctors touched on new techniques (such as the T-cells), but there wasn't much that was going to come out very soon. However, I asked them the question about how long was it reasonable to expect a Folfirinox patient to be able to remain on the drug and was it recommended to take a periodic break to allow the patient to regroup and build back up a bit (in other words, is there a point where the drugs designed to kill the cancer end up killing the patient as well because of the cumulative levels of toxicity building up over time). Both doctors agreed that it was a matter of quality of life and should the patient want to "take a holiday" (their words), there's no reason why that can't be done and, in fact, this type of approach is relatively common. For me, I'm having considerable difficulties from the side effects (I have a 6 1/2 hour infusion every 2 weeks, then a take home slow drip for another 48 hours) and cannot imagine how I might be able to manage staying on this regimen in perpetuity. So, I intend to take the periodic holidays as a means of pushing out the time period over which I can tolerate the drugs (and hopefully, at some point, some more effective and curative drugs will come along before it's too late).
      Perhaps your mother might ask about the periodic holiday approach at her second opinion appointment in July. Hope this is at least a bit helpful. JMS

      about 8 years ago

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