• I was told my tumor was HER neg but still waiting on the PR and ER status' I cant seemed to find what this means?

    Asked by LMUmom on Wednesday, September 19, 2012

    I was told my tumor was HER neg but still waiting on the PR and ER status' I cant seemed to find what this means?

    I have been dx'd with stage III locally advanced ( 6.5 cm x6cm) no lymph node involvement, doing excellerated neo-adjuvant Chemo A/C Oncologist tells me the treatment wont change regardless of status' so I dont know why its so important HELP!!!!

    12 Answers from the Community

    12 answers
    • ticklingcancer's Avatar

      I was able to find this article, I hope this helps explain things a little better. Hopefully someone with a similar diagnosis will chime in. Good luck with your treatments.


      about 4 years ago
    • lynn1950's Avatar

      Hi - If you are Her2 negative, you won't take herceptin. Her-2 positive cancers have a different prognosis from Her-2 negative. Knowing your PR and ER status (whether or not progesterone or estrogen play a role in your cancer) helps to determine if tamoxifen or an aromatase inhibitor will be effective once you have finished your current treatment (probably radiation, chemotherapy, and surgery). So it is important! Hugs to you. xoxoxo Lynn

      about 4 years ago
    • nancyjac's Avatar

      PR stands for progesterone receptive and ER stands for estrogen receptive. A positive result for either indicates that you cancer has mutated in such a way as to provide progesterone and/or estrogen receptors in your cancer cells. When progesterone and/or estrogen bind with those receptors in aids the cancer cells in growing and reproducing.

      Your current chemo won't change. However, it does matter for subsequent treatment to reduce or block the amount of progesterone and/or estrogen available to cells. Hormone treatment is not normally started until active treatment (e.g. chemo, surgery, radiation) is completed. Hormone treatment is used to reduce the risk of cancer recurrence, not to kill currently identified cancer cells.

      about 4 years ago
    • FreeBird's Avatar

      The best person to ask what that means for your care is your doctor. Here is what the (U.S.) National Cancer Institute has to say:


      Note that PR and ER stand for Progesterone Receptor, and Estrogen Receptor.
      HER stands for Human Epidermal growth factor Receptor.

      about 4 years ago
    • osu2sum's Avatar

      I am triple negative, which means that chemo and surgery were the options available to me. I just finished with chemo in July and had my final surgery last week. If you'd like to chat more after you get your diagnosis, I'd be happy to share my journey. Carol Ann

      about 4 years ago
    • ruthieq's Avatar
      ruthieq (Best Answer!)

      er/pr status tells the doctors whether the tumor was hormone dependent (needed it to grow) If positive then you will need to take Tamoxifen or Aromatase inhibitors. Tamox is for those who are not menopausal, AIs for those who are post menopausal. If you were Her2 positive you would also be taking Herceptin with your chemo. The fact that you are neg for her2 means your cancer is less aggressive. Thats a good thing! :)

      about 4 years ago
    • Harry's Avatar

      Don't you just love jargon? :-) I'm glad others were able to sort this out because I wouldn't have been able to.

      I have to echo the comment about asking your doctor to explain. Insist that he explain everything you don't understand. You won't sound stupid. Stupid is not asking. He should explain, without talking down to you, everything he says. He may also be able to point you toward resources that explain better.

      about 4 years ago
    • SandiD's Avatar

      Go to www,breastcancer.org for really good info. I relied on that site a lot and, as a survivor, still do. I am ER & PR positive. You will learn all the cancer jargon. Ask questions and educate yourself. You will feel more in control when you do. Good luck to you! There are a lot of us Survivors out here!

      about 4 years ago
    • LMUmom's Avatar

      thank you so much everyone for responding! I feel so much better lol.... I will definitely ask my onc next time I see her but as we are waiting the results to be transferred from one hospital to another it could take some time to get those results.
      this is all so new to me and although I don't feel overwhelmed or stressed, I feel somewhat like information overload!!! thanks again

      about 4 years ago
    • carm's Avatar

      Hi I am an oncology nurse so maybe I can clear it up although it looks like many have given you the answer. If you were tested for the BRCA mutations, then if you are BRCA 2+ you would have hormone driven carcinoma. If you are BRCA 1+ this means you are a triple- negative which means estrogen receptor, progesterone receptor, and human epidermal growth factor 2 receptor negative so it would be HR-, PR-, HER2-. Your cancer would be caused by a genetic mutation on a chromosome (13 or 17). So the therapy would be chemo and not hormone therapy. I hope this clarifies.

      about 4 years ago
    • EFalconbury's Avatar

      Good Morning, My name is Elaine. I have been through treatment for breast cancer. I am stage IIIC, I am HER neg and neg for all of the harmones. What I was told was that the hormone + people and HER + can receive a medication after treatment that retards the cancer from ever coming back. I am - so the medicine will do me no good. She told me that mine will probably come back but we have many people praying that she is wrong. God is my blessed controller of all things.

      about 4 years ago
    • Harry's Avatar

      Just a follow-up. There was an announcement in the news this morning that MD Anderson in Houston was initiating a "moon-shot" program to find cures for 10 types of cancer. Triple negative breast cancer was one of the targeted cancers.

      about 4 years ago

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