• If low grade marginal zone NHL turns into a high grade NHL will the subtype change? What is the most common subtype if this happens?

    Asked by rcar2010 on Sunday, October 28, 2012

    If low grade marginal zone NHL turns into a high grade NHL will the subtype change? What is the most common subtype if this happens?

    Last year I was diagnosed with an indolent (nodal marginal zone b-cell)NHL. Found out last week that lymph node biopsy now shows high grade lymphoma. Since nodal marginal zone B cell NHL is an indolent, or low grade subtype, I'm wondering if my subtype will change and if so what is the most common high grade subtype this type of low grade NHL becomes. I apologize if this question is confusing but I was just getting used to having a low grade lymphoma and now everything has changed. I won't see my Oncologist for 10 more days so I'm hoping someone can answer this so I'll have a better idea of what I'm dealing with now.

    5 Answers from the Community

    5 answers
    • nancyjac's Avatar

      Please see: http://www.macmillan.org.uk/Cancerinformation/Cancertypes/Lymphomanon-Hodgkin/TypesofNHL/NodalmarginalzoneB-cell.aspx#.UI271m_A_Kc

      In marginal zone lymphoma, the changes in the cell occur in an area of the B-cells called the marginal zone. Nodal means that it starts in the lymph nodes. Low grade means the cell changes have been growing slowly. Occasionally it may change (transform) into a high-grade non-Hodgkin lymphoma, which needs more intensive treatment. It is still nodal marginal zone b-cell NHL in which the cell changes have gone from growing slowly to growing faster.

      almost 4 years ago
    • nobrand's Avatar

      Hey-- I'm sorry to hear that your biopsy is now showing high grade lymphoma. On the bright side, the high grade types are much more chemo sensitive, so a cure is possible!

      As for the rest of your question: I know what you're asking, and sadly don't have an answer for you. Perhaps someone else knows. Best of luck on your journey.. I'll let you know if I come across the answer!

      almost 4 years ago
    • nicegal's Avatar

      Hi, I was diagnosed with nodal Marginal Zone lymphoma in early 2007, stage 3b. I was on watch and wait until 2011. when nodes in my neck began to grow. In February 2011 I started a course of oral chemo - chlorambucil - then was admitted to hospital with fevers in April 2011. In May a biopsy showed DLBCL (diffuse large B- cell lymphoma. I received 6 cycles of R-CHOP and was NED for one year, but now the DLBCL has returned. I asked my doctor whether the chemo got rid of the MZ as well as the DLBCL but he didn't know, and the most recent biopsy was done to find out which of the cancers had returned. Hope this helps.

      almost 4 years ago
    • Nora's Avatar

      Hi there, what part of your body did they do biopsy on? And how did it go? How big
      Was the insicion?

      almost 4 years ago
    • nicegal's Avatar

      I don't know if I am answering the right question or in the right place so bear wirth me. The biopsy was in the front right side of my neck, the incision was about 3 inches long and it is healing nicely.

      almost 4 years ago

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