• Joy's Avatar

    Im a breast cancer survivor (triple negative, 1yr out). My GGT/ALP have been elevated/normal and now I have to have liver biopsy-comments?

    Asked by Joy on Saturday, December 15, 2012

    Im a breast cancer survivor (triple negative, 1yr out). My GGT/ALP have been elevated/normal and now I have to have liver biopsy-comments?

    I was wondering if anybody else has experienced this. Thanks for your input.

    4 Answers from the Community

    4 answers
    • nancyjac's Avatar

      I wouldn't pull out the cancer card quite yet. Many things can cause elevated GGT/ALP including alcohol, congestive heart failure, and any type of inflammation, infection, or injury involving the liver. Best of luck with your biopsy.

      almost 4 years ago
    • SueRae1's Avatar

      Many many hugs. It may turn out to be nothing. I triple negative breast cancer lesion was found on my liver in April/May of this year (just one year after I completed radiation treatment) - the lesion was picked up during my regular scans for my advanced renal cell carcinoma. After the lesion was found my marker tested elevated/normal. The good news, there is lots and lots of great treatments out there. My latest scans show that my tumors are shrinking and all markers are normal. Please feel free to contact me if you need any support, or information. Wishing good luck on your biopsy.

      almost 4 years ago
    • JennyMiller's Avatar

      As much as we want our doctors to be thorough and follow up, it is downright scary and stressful. However, good results lift our spirits and renew our confidence. I wish you the best!

      almost 4 years ago
    • carm's Avatar

      Hi Joy, and what a beautiful name. My name is Carm and I am an oncology/end of life nurse. I saw your question so I thought that maybe I could clear it up a bit. GGT or gamma-glutamyl transferase is an enzyme that is found inside of liver and pancreatic cells. When these cells get injured, that enzyme leaks out into the bloodstream and that is where it is detected. So there are many reasons why these cells could be injured. Of course, the fact that you are a cancer patient I have to mention metastasis; but other reasons for elevated GGT are cirrhosis, hepatitis, jaundice, a heart attack, and some viruses like EBV, or CMV to name a few. Those sound scary and they can be if they apply however, there is also the possibility that some chemotherapies can damage the liver cells because they are toxins, and are very harsh. The liver is one of those organs that regenerate their cells so an injured cell will be replaced, but if the cause is a carcinogen, it could continue to elevate, and so I assume that your doctor is probably just making sure that your liver is not over-assaulted. Because triple negative is so aggressive, it is often the treatment that causes the elevated GGT, and not the disease. A this point you are at an impasse awaiting that biopsy, but if it turns out to be mets Sue Ray is right on the money in that there are great treatments for liver mets, and they work rather fast. The liver is very vascular so it is easy for the chemo to really penetrate the organ and it usually clears up pretty fast. I hope the biopsy goes well for you and that it just ends up being a matter of switching or redosing your treatment. Best of luck to you, Carm.

      almost 4 years ago

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