Everyone is different but I imagine you will be quite nervous, more than likely your doctor will give you something to take the night before to help you to relax. My infusions lasted 6 hours and I always choose to bring my walkman (yes I said walkman not IPOD as it was way back in the late 90's) and listen to my favorite music and drift off to sleep during the infusion. Do try to relax if at all possible, it is truly not as bad as most imagine it to me. Yes you may get sick so be sure to take the meds the doc gives you at the designated times as that will help you with neausea. It is helpful to start writting your treatment questions down now as you will not remember them once you are in front of the doctor. Keep a note pad handy that you can jot your question down on and take it with you to your appointments. Be sure to drink plenty of fluids on the day of chemo and a few days afterwards to help flush your system. You will most likely be quite tired so rest as much as you feel the need to, you are not being lazy you are actually being smart and taking good care of yourself. You may find that you lose your appetite so eat small portions as often as you feel like eatting (you want to keep your nutrition up). Those are a few of the things that come to mind. The important thing to remember is that chemo is a means to an end and it is doable. You can do this, you can get through this and once you do you will regain your strength with time. My best to you!