Hi Blue. I have not heard of that connection. My dad did not take enzymes, but I know exactly what you're talking about. I don't know enough about it. I would ask the pancreatic cancer action network pancan.org
He did however, and still does experience ankle swelling. There are a number of things that could be going on here, so it's worth mentioning it to your doctor. Is it in both legs? How are you eating? Are you experiencing a weight gain?
Two remedies for dad-- first is elevating his legs above the level of the heart when he's sitting or laying. Second, if the swelling gets too bad, they prescribe a diuretic. He was holding quite a lot of water recently.