• Is hormone therapy an option after radiation has not killed all the cancer?

    Asked by HardyGirl on Thursday, March 14, 2013

    Is hormone therapy an option after radiation has not killed all the cancer?

    I worry that there is still cancer.

    4 Answers from the Community

    4 answers
    • nancyjac's Avatar

      Hormone therapy is used as a preventative measure only when a cancer is estrogen receptor positive. Hormone therapy either blocks estrogen from attaching to cell receptors or depletes the amount of estrogen available. It does not kill cancer cells, it provides a less hospitable environment for their regrowth.

      over 3 years ago
    • carm's Avatar

      You pose a very interesting question, and I think that it is wonderful that you are considering options proactively. When it comes to hormone therapy for endometrial recurrence, progesterones have been used in the management of recurrent endometrial cancer. I think parenteral hydroxyprogesterone caproate (Makena) was used in trials that showed some successes. These trials were followed by the use of MPA (megestrol acetate), or Megace; a high dose progsterone therapy. However, overall at the time of these studies, fewer than 30% of patients in the trial showed any objective responses. As of late, Tamoxifen has been used in combination with MPA, and that has shown a much better outcome. There are other hormonal manipulations that were and continue to be under study since Tamoxifen and MPA. They are selective estrogen receptor modulators like raloxifene (Evista), luteinizing hormone-releasing hormone agonists and antagonists, aromatase inhibitors, and other miscellaneous drugs like Danazol (a synthetic modifying progesterone), if I recall correctly. But Danazol (AKA 17-alpha-ethinyl testosterone) had some wicked side effects and started masulinizing women on the trial. In the 70's however it was effective in treating endometriosis but it is rarely if ever used now. I hope this gives you some insight to your query, and I think that it is so great to see patients thinking outside the box. I am not sure if you have checked out the Foundation for Womens Cancer website, I think you might find the answers you seek there. Best of luck to you and I hope that all this information is unnecessary and that you have successfully climed out from under that cloud of uncertainty. Carm RN.

      over 3 years ago
    • Kathy's Avatar

      I just wanted to say I like your profile picture!!! It's perfect!

      over 3 years ago
    • HardyGirl's Avatar

      Thanks Nancy and Carm. That helps me.

      Kathy, thank you, I've just about beat it, I plan on beating it all the way!

      over 3 years ago

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