• Is losing your grip strength and hand weakness normal with Folfox?

    Asked by mtnraindancer on Wednesday, December 5, 2018

    Is losing your grip strength and hand weakness normal with Folfox?

    I just had my third treatment. First two I breezed thru with only a slight claw hand on the second one that lasted just for a bit. This time, the tingling and shock sensation in my hands arrived hard and strong in the evening after I got home with my pump and weren't cold related at all. This morning I noticed a weakness in the grip of my left hand which is slowly getting better. I started L-glutamine yesterday and I have also read that calcium and magnesium infusion gave great relief. Any information you can share with your own experiences and possible remedies would be greatly appreciated. Hugs and a beautiful day wished to all of you!! Missy

    5 Answers from the Community

    5 answers
    • JaneA's Avatar

      I never suffered grip strength problems with FOLFOX - had 12 cycles.

      However, every person reacts differently. I just looked at my old ChemoCare and muscle weakness is an occasional side effect of FOLFOX.

      It's best not to take supplements without consulting your oncologist first - some interfere with the effectiveness of your chemo. Best wishes to you. Hugs from a Stage IV rectal cancer survivor!

      6 months ago
    • po18guy's Avatar

      Is it just FOLFOX, or are steroids involved? Prednisone, for one, causes muscle wasting. As to grip strength, some drugs may have that effect, either througfh muscle decrease or neuropathy. I was in a trial of Arzerra (Ofatumumab) and grip strength was one of the follow-up tests. I would call and ask doctor/nurse about it and peruse the various drug makers' websites.

      6 months ago
    • mtnraindancer's Avatar

      I am on FOLFOX with Avastin...I am given IV steroids along with Emend for nausea and then two days of steroids orally when I come home with the pump. The tingling and "pins and needles" sensation were pretty strong this time. My grip was definitely affected but didn't last long. My mouth also seemed to draw inward a couple of times. Very strange sensations but from what I've read, others have had the same. I guess all of us are individual beings and respond differently. I started taking L-Glutamine powder and like everything else, you will find 100 studies to support it and another 100 that won't. It so helps to share with others who are in the trenches with you. Big hug to all!

      6 months ago
    • myb's Avatar

      I would report this to your oncologist. When I finished 12 rounds of folfox, i noticed I lost hand grip strength. During chemo I got hand cramps, so started taking alpha lipoic acid which helped. I got 24/7 hand and feet tingling 1 week after I finished the 12 rounds. During chemo it was just the reaction to cold items that had me tingling. I did the free Livestrong program after I finished chemo at a local YMCA and it helped to get my strength back and the balance issues from neuropathy that I got after chemo too. I suggest looking to see if one is near you but maybe wait till you are done chemo. (https://www.livestrong.org/what-we-do/program/livestrong-at-the-ymca)

      5 months ago
    • Skyemberr's Avatar

      In my case the tingling during FOLFOX indicated that it was acting as a neurotoxin in my system. I have permanent numbness in some areas and numbness in my left hand that occurs several times a day.
      Peripheral neuropathy can be an extremely serious sign of a complication, so you should be very very clear with your nurse and doctor that you have it so they know to assess you for having the neurotoxin complication, which can be fatal if it is allowed to progress long enough..

      5 months ago

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