I know so many people on Tarceva..all doing very very well. Still working still living a normal life except for a bit of stomach bloat and frizzy hair. But one of my close friends in California is a runner and full time Nurce Practicner and does not skip a beat.
Been on it three years.
I think there is a blog Tarceva dudes and dudetts.
Good news is a number of drugs in the pipeline to counter any possible resistance.