• Is your fatigue from Epigenetic changes to your DNA due to Chemo?

    Asked by jhale17 on Thursday, September 7, 2017

    Is your fatigue from Epigenetic changes to your DNA due to Chemo?

    Have you heard any explanations for lasting fatigue in cancer patients treated with chemotherapy? Here are a descriptions of causes I have read about. Have you heard of any other reasons?

    Chemo can cause epigenetic changes to the DNA. This often results in cancer- patient fatigue. An analogy of what happens is to think of the gene as the hardware in a computer that awaits instructions on how to express itself (how to function.) There are proteins on the outside of the gene that act much like computer software to instruct the genes do what they are supposed to do. The chemo damages the outside of the gene (like when software crashes) and the gene malfunctions. One result is patient fatigue. Patient side effects from this may be be during treatment and/or may last long-term.

    7 Answers from the Community

    7 answers
    • BoiseB's Avatar

      Cancer and all treatment hit us pretty hard. As well as opening the door for all those diseases we were previously fighting. I have all my life fought periods of chronic pain and fatigue these bouts lasted for a few weeks to a month and occurred every nine months, Guess what after cancer the chronic pain and fatigue are here to stay. Dr.s have tried to separated these symptoms out but they have given up. People I have talked to believe that their fatigue was caused more by radiation than chemo. But they both treatments kill healthy cells as well as cancer cells and radiation does alter DNA

      over 2 years ago
    • kdavis11259's Avatar

      I don't know if this will help or not, but I used to be so tired and had no energy before and after treatment for follicular lymphoma. I went to the health food store and they recommended a vitamin supplement called Blood Builder by Mega Food. It is a supplement containing Vitamin C, Folate, B-12, and iron. The thing that, I believe, makes it superior to other supplements is that it all comes directly from food sources. For example, the vitamin C is derived from organic oranges, the folate from broccoli, etc. It is more easily absorbed and is easy on the system so that you can even take it on an empty stomach. It has helped me regain my energy to where I actually feel like my old self again. I swear by it.

      over 2 years ago
    • cards7up's Avatar

      I have long lasting fatigue from my treatments and just live with it. I consider it part of my new normal like dealing with scar tissue. I don't nap every day but close to it. Thankfully I don't have to work and my schedule is pretty much my own. I still end up with a long day even with a nap! I'm an early riser and later to bed.

      over 2 years ago

    Help the community by answering this question:

    Create an account to post your answer Already have an account? Sign in!

    By using WhatNext, you agree to our User Agreement, and Privacy Policy

    Read and answer more diffuse large b-cell lymphoma questions.  Also, don't forget to check out our Diffuse Large B-Cell Lymphoma page.