• long term plans

    Asked by sugarbear on Saturday, May 11, 2013

    long term plans

    im wondering what plans people that are on zelboraf have for when the z stops working -have asked drs which way to go and am hearing conflicting stories

    4 Answers from the Community

    4 answers
    • carm's Avatar

      Hello, I am an oncology nurse and you pose an interesting question. Zelboraf (vemurafenib) is a targeted therapy, it is a B-RAF kinase inhibitor and indicated for use in melanoma especially if you have the V600E mutation ( a missense or translocated mutation on the 600th codon in your DNA chain where V=valine, an amino acid, was substituted for another amino acid E=glutamic acid). There are other new targeted drugs that are slated for approval as soon as next month as early as the 3rd of June. They is another B-RAF kinase inhibitor called Dabratenib (chemical name) and also a MEK protein inhibitor called Trametinib (chemical name), which has also shown to be effective in melanoma. There is also the prospect that another drug could be added to the Zelboraf like Nexavar (Soratenib). If you notice the one continued theme for these drugs is that all their chemical names end in ib. IB denotes that this is an internal binding drug or targeted therapy; this is an important thing for you to know when discussing treatment options with your doctor. Knowing the mechanism of action of a drug will help you to know what to look for and in what direction the doctor is going, whether with another target therapy or back to a one size fits all chemotherapy. Best of luck to you, Carm RN.

      over 3 years ago
    • Dick_K's Avatar

      Options are changing fast. For me, I stopped trying to have a plan B in place if I have to stop Zelboraf. I try to keep up with the current trials and news. ASCO 2013 is coming up at the end of the month and good news generally comes out of it. I’m working on my 38th month on Zelboraf; be sure you understand there are long term responders – I hope you can be one.

      over 3 years ago
    • CAS1's Avatar

      Dick -K has it exactly right..Once a Drug comes out there will be numerous Pharm companies who will work on drugs to address the resistance component. Everything is coming so fast now that Dr's are reluctant to say a plan B..Go visit Collabrx or Cancer commons to see the efforts to bring research data and solutions to market even faster than before.

      Dick is also right about the ASCO..I am waiting too with hopeful anticipation of the new data on clinical trials..

      Friend..take it day by day.. I take my life in 3 month intervals.

      There is real hope out there.

      over 3 years ago
    • CAS1's Avatar

      Hey,,Richard...did you see the system blocked out your short name?? its replaced with xxx

      Greg..a little too sensitive don't you think??

      over 3 years ago

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