• Metaplastic carcinoma HER2 & ER +

    Asked by happness on Sunday, August 18, 2019

    Metaplastic carcinoma HER2 & ER +

    I have metaplastic carcinoma with chondroid differentiation that is HER2+ and ER+. Does anyone else here have this combo or know much about it?

    2 Answers from the Community

    • carm's Avatar
      carm

      @happness,
      Hello, I am an oncology nurse and maybe I Can give you some insight. Metaplastic carcinoma (MpBC) with chondroid differentiation is a rare subtype of breast cancer. 
      It is usually a very high grade, and mostly ER-, PR-, and HER2-negative. So... MpBC with a positive reaction to ER, PR or HER2 are less common.
      Generally, most breast cancers cells arise from the glandular tissue of the breast however, metaplastic breast cancer is made up of other types of cells or other types mixed with glandular cells. Normal breast cells are called epithelial (glandular) cells but MpBC will also have mesenchymal cells (bone, skin or muscle) cells. That's the hallmark of MpBC. The general treatment is the same that most women with hormone positive cancers receive. First line is either TC (Taxotere and Cyclophosphamide) or TAC (Taxotere, Adriamycin and Cyclophosphamide) followed by maintenance of either Tamoxifen or an Aromitase Inhibitor plus maintenance Trastuzumab. I hope this helps and best of luck to you.

      3 months ago
    • earthgirl's Avatar
      earthgirl

      We are not quite the same as I have Metaplastic Triple Negative Breast Cancer diagnosed in January. As @carm indicated, it is a very high grade, and I am ER-, PR-, and HER2-negative. My surgeon (I had a quandrantectomy) and oncologist indicated the need for chemo and radiation because of the aggressive nature of metaplastic carcinoma. I just finished four chemo treatments of Adriamycin and Cytoxan (three weeks in-between doses) and in two days, I begin 12 cycles of weekly Taxol. This may not be very helpful because of the difference of the chondroid differentiation in your diagnosis but I don't see metaplastic posts too often myself. I wish you the best as you move forward.

      3 months ago

    Help the community by answering this question:

    Create an account to post your answer Already have an account? Sign in!

    By using WhatNext, you agree to our User Agreement, and Privacy Policy


    Read and answer more triple-negative breast cancer, ductal questions.  Also, don't forget to check out our Triple-Negative Breast Cancer, Ductal page.