• My husband just got the BRAF mutation POSITIVE result. What exactly does it mean? He has stage 3b melanoma.

    Asked by dora201077 on Wednesday, November 7, 2012

    My husband just got the BRAF mutation POSITIVE result. What exactly does it mean? He has stage 3b melanoma.

    The doctor told me that it will be useful in the future (in stage 4), for treatment. Is there someone doing specific treatment after BRAF mutation turning positive, in stage 3?

    5 Answers from the Community

    5 answers
    • carm's Avatar
      carm

      BRAF mutation. Is a mutation on throw KRAS mutation and the benefit of this is that there are selective drugs that will inhibit the growth of the BRAF mutation gene. BRAF is very common in melanoma. The staging should not matter as much as that message that even in stage IV these drugs are effective. Good luck, Carm (oncology nurse).

      almost 5 years ago
    • bjsimme's Avatar
      bjsimme

      You can take Zelboraf chemo pill has helped keep my turmors the size they are and no new ones developing. Blessings to you keep on praying for complete healing.

      almost 5 years ago
    • nancyjac's Avatar
      nancyjac

      BRAF is one of many genes that can cause cancer when they mutate. The significance of knowing that to be case is one of many factors in the treating the cancer.

      almost 5 years ago
    • Dick_K's Avatar
      Dick_K

      Being positive for BRAF V600E could make you eligible for Zelboraf (venurafenib) if your tumors are unresectable. There are also clinical trials for stage III patients.

      almost 5 years ago
    • Terri's Avatar
      Terri

      If you are born with the BRAF gene, you have birth defects. When it mutates as you age, you get cancer. I have it. I don't know why the gene turns on. On a recent webinar from UCLA, the Dr. said it is the equivalent of smoking 50 packs of cigarettes every day of your life. That is the DNA damage that causes melanoma. sobering thought.

      almost 5 years ago

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