• My melanoma has gone to my lymph system and my doctor is talking about the B-Raf mutation. I feel lost in translation. What does this mean?

    Asked by Sunnysideup on Tuesday, January 29, 2013

    My melanoma has gone to my lymph system and my doctor is talking about the B-Raf mutation. I feel lost in translation. What does this mean?

    3 Answers from the Community

    • nancyjac's Avatar
      nancyjac

      Your lymph system is a body wide network of nodes and conduits that remove excess interstitial fluid from soft tissue and transports white blood cells to and from you bones. Your lymph system is one of two ways (the other being your blood stream) that cancer can metastasize beyond the primary area of origin.

      BRAF is a human gene that makes a protein called B-Raf. Mutations in this gene have been found in cancers, including melanoma. More than 30 mutations of the BRAF gene associated with human cancers have been identified. One or more BRAF mutations are found in over 80% of melanomas. The good news is that that is a drug (Vemurafenib) that is a BRAF inhibitor and can be used as targeted therapy.

      over 4 years ago
    • Dick_K's Avatar
      Dick_K

      The actual mutation that you would be tested for would be for the presence of BRAF V600e. Depending on the study used, approximately 50% of melanoma patients have the BFAF and of that 50%, approximately 80-90% have V600e.

      Zelboraf (vemurafenib) was approved by the FDA in 2011 for stage IV and unresectable stage III melanoma. I am stage IV and next week I will have been on Zelboraf for 35 months.

      over 4 years ago
    • StrongSteph's Avatar
      StrongSteph

      well.....Nancy answered the BRAFF question really well. I would ASK YOUR doc about anything unknown. I hope he/she is approachable and you feel as though you can ask questions. Also, when I was sick I did research of my own.....information is power. best to you!! :) Steph

      over 4 years ago

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