That varies from trial to trial depending on the criteria and baseline for a given trial. Her oncologist's office or chemo treatment center should be able to provide information on any trials she may qualify for.
Serous Type Questions
My sister has stage3c ovarian cancer . She has gone through two cycles of different chemo and is now platinum resistant or refractory.
Asked by moecarmac on Thursday, August 16, 2012
My sister has stage3c ovarian cancer .
She has gone through two cycles of different chemo and is now platinum resistant or refractory.
How is decision made about suitable trials?
5 Answers from the Community
You give no hint of what yours has recomended. The best oncologist to use is a gynicologic oncologist surgeon. Has all the cancer been removed that can be? In January of 2006 when I was 62 I was diagnosed wiht Stage IV (4) ovarian cancer. I was sent to a GOS. Back then they were a brand new specialty... There were only four in the state back then. AND I'm in Minnesota with the Mayo Clinic... Thus he did the surgery and removed all the cancer he could see. A 39 lb tumore, my ovaries (of course) and scraped it off my intestine and my euretha. I developed an infection and this delayed the start of chemo. The PET CT Scan revealed that this wonderful surgeon had removed all cancer. Now since Ovarian likes to come back... he started me on a treatment that involved I/V infusion and I/P infustion of the chemo. Six cycles of three infusions each over the 28 day cycle. Day one I/V infusion... Day Two I/P infusion (or directly into the peritineal cavity (abdomine). Then Day eight I/P infustion again. Bercause of Neulasta injections I only missed one I/P infusion (Day 8 of the first cycle and my blood was too low to handle it. From there on I recived all infusions and then a shot of Neulasta on Day 9. When I had completed all six cyles the PET CT Scan still showed No Cancer. But this marvalous oncologist was not through. I had told him I wanted to fight... and fight we did. He had heard about another treatment that proved so helpful in the clinical trial that he wanted me on it. It was another year of chemo I/V infusion only... once a month for twelve months. We did it. I have remained cancer free with a CA125 of 5.6 in July this year. I have a CA125 every three months and an internal every six months.
Thus, get with your oncologist, and trust them to give you the options that you have. If you do not trust this oncologist... ask to have a consult. Then trust that they will steer you to the right treatment for you.
When diagnosed I put my life in God's hands. I asked him to hold my hand and lead me on the path He wanted me to follow. I'd follow him anywhere but I was so terribly frightened. He took my hand instantly, my fear was gone. I am here almost 7 years later. Place your trust in God and know that He wants only the best for you! God Bless.
Im not sure what it is that you are asking, but I am an oncology/end of life nurse who used to do clinical research for various drug companies, so if you are interested in information on trials for your sister, let me give you a few pointers. First, if you want to know what is out there, you can look at sites like centerwatch or acurian to see what is available. If you find one that is interesting, the first thing to look for is to find out what phase the study is in. Avoid all phase I and II if you can, these are dosing stages. They are not testing the drug for effectiveness in phase I but to see what dose is safe and what interactions come about. In phase II it will test the effectiveness but only on a limited number of people in case there is a serious side effect that was not apparent in the animal studies. Always look for phase III or IV. In phase III they cast a wide net to test its effectiveness and this is the phase that can make or break a drug. In phase IV, the drug is approved and it is usually an open-label trial where you are not comparing it to another drug, you are getting the new drug and now that it is approved, they want to see if there are any long term effects. Once you find the study that suits you, look to see if they are recruiting patients or is the study closed to your sister. If they are recruiting and it looks promising then the next thing to look at is the inclusion/exclusion information. Does she qualify to be in the study. Here is where they might ask for specific age groups or a patient with no co-morbidities like heart disease or renal disease. If she fits the inclusion and there are no items that could exclude her, then you can look to see where the study is being conducted near her. There should be a phone number to call associated with the site. Good luck with your search, Carm.