• nausea from chemo and drug concerns

    Asked by justoneman on Saturday, January 10, 2015

    nausea from chemo and drug concerns

    The side effects after my wife's second chemo session were worse than the first. She says she has cramps all over and the nausea is overwhelming. The doctor gave her a prescription today for Metoclopramide. The side effects on the paperwork supplied by the pharmacy scared the heck out of my wife so she will not take it. Has anyone taken this drug and can give me your experience with it? I am watching my wife struggle and it is tearing me apart. I bought different brands of peppermint teas, several ginger products, ginger root, ginger ale and peppermint candy. Nothing helps and if this drug is not good I have no options. I will be asking the dr for an alternative but am interested to hear anyone's thoughts on the Metoclopramide.

    19 Answers from the Community

    19 answers
    • IronMom45's Avatar

      Promethazine 12.5 mg one to two tablets every 6 hours and 8 mg of zofran every 8 hours. Works for me. Usually don't even need the zofran just promethazine, but if do need the zofran take it about 3 hours in between the 6. I'm very familiar with metoclopromide or reglan it's other name, it works ok for some but not as great as others. Long term use more likely cause side effects. There is the emend that can be given prior to infusion if that hasn't been added maybe check into it. Also there is compazine and tigan for nausea. Reglan should be ok to try at least while waiting to see if can get something else. Hope feels better!

      over 6 years ago
    • leslie48240's Avatar

      My chemo treatments ran from 12/2007 to 4/2009 so there may be new better things now....but I was given Emend (1 pill the day before/one the day of/and one the day after) and had absolutely NO nausea. I also drank as much water as I could ...but especially those same 3 days. Flushes the chemo out of your organs. Hope she finds something to help her. Sorry she is having such an awful time. I have heard it is important to prevent the nausea to start with as it is much harder to stop it once it starts. Be sure she tells her chemo nurse and Dr...as they may cut back on the amount or speed of delivery of the chemo also.

      over 6 years ago
    • ChildOfGod4570's Avatar

      OH, I am so sorry to hear she is going through all this with nausea and seeing a scary list of side effects on the medicine's paperwork. Though I did well with the anti-nausea meds they gave me duringmy infusions, I had other rough reactions to chemo, so you might want to talk to the doctor about putting some precautions in place for her, especially since it looks like the effects for her may be cumulative. Is she already taking steroids the day before, the day of, and theday after chemo? Perhaps she needs a 10to 20 % reduction in the drugs themselves; I needed these aforementioned precautions due to my being very sensitive to drugs. Is she holding anyting down at all? You might want to start her eating gentle things like Saltines if she can handle them. Does yogurt help her? That also helps with stomach issues, and if she is afraid to eat, please encourage her to drink meal replacement drinks; she will need al the strength she can get. My other suggestion was ginger root pills, but you said those don't help her. Oh, if only I could be more helpful to her. HUGS and God bless you for being such a wonderful and loving husband!

      over 6 years ago
    • kghalva's Avatar

      there are plenty of good meds out there now to control the nausea, keep after the doc until she gets on the right combo. I get pre-meds before the infusion to take care of the nausea, check and make sure she is getting something. That 'carries' me thru for a couple of days, then I have compazine and zophran to take at home, keeps it totally under control. The pre-meds include a steroid, zophran, benedryl, ranitadine, and tylenol. No bad effects from any of the drugs for nausea, and believe me, I've had plenty of bad side effects from other things! Once the nausea is somewhat controlled, figure out what foods/drinks sit well - I like Coke, crackers, yogurt, toast and bananas. Nothing too spicy, and homemade chicken noodle soup is my go-to comfort food. Sometimes too much water isn't good, but it is important to drink as much as you can to flush out the toxins. Good luck finding the right combo to provide some relief for her!

      over 6 years ago
    • lujos' Avatar

      I was prescribed the same drug, as a 'take this if you need to' drug, if the Zofran alone wasn't enough to control the nausea. I read about those side effects, too - quite scary indeed, and luckily my nausea wasn't so bad that the Zofran didn't take care of it.

      Has she been prescribed something like Zofran or Emend as first-line nausea prevention? I think that is fairly standard - though Zofran is pretty pricy, it does work.

      I think the ginger/peppermint trick is great, and helps me a lot, but I think anti-nausea drugs of some type are a must, so that the nausea doesn't get on top of ou.

      over 6 years ago
    • Stylerman's Avatar

      I went down the same road as your wife. Finally ended up with Emend and the Sancuso patch. Both work well for me. Good luck.

      over 6 years ago
    • myronbob's Avatar

      please stay in constant contact with oncologist nurses till problem eases , also remember to take pills 2 days ahead of treatment ,and if approved .water, water and more water .good luck bob

      over 6 years ago
    • annogden's Avatar

      Like Leslie, I was given Emend, and except for very occasional queasiness the week after chemo, had no nausea whatsoever. Ask your doctor for it. They may not be giving to you because it's an expensive drug but it truly relieves the misery.

      over 6 years ago
    • fiddler's Avatar

      Neulasta, when they add it to the protocol, makes it worse, just so you know what's what.

      over 6 years ago
    • Kathy1's Avatar

      Ahh that's awful. I understand. The longer I went the worse the nausea was. My doctor gave me a cocktail of drugs that I would start taking the night before chemo and continue taking it for at least three days after. It was Promethazine 12.5 mg, Zofran and Lorazepam 1mg. Yes it does make you sleepy but I thought that was a better alternative. It worked. I am aware of other chemo patients who were on the same cocktail so it must be common. I am not familiar with the drug yur doctor prescribed all I can tell you is what worked for me. I wish her the best. I really understand what she is going thru! Take care!

      over 6 years ago
    • rwhdesmoines' Avatar

      I am sorry forwhat your wife is going through. A few of my most difficult experiences with nausea/vomiting related to chemo in the last few years were helped greatly by going to the er for a few doses of iv anti-nausea medicines and extra iv fluids. For me once my vomiting was under control with the iv meds I was able to once again rest comfortably at home.

      over 6 years ago
    • tuwood's Avatar

      I don't know about Metoclopramide... I was given Emend (three pills - one the day of chemo and one a day for the next two days). It is VERY expensive, but if insurance doesn't cover it, you can get help from the pharmaceutical company. Drink LOTS of water (I drank 48 ounces during the infusion, and 48 ounces after)... It helps to get the chemo out of your system quickly. I also received a Neupogen shot afterward... It gave my body the strength to fight back. My heart goes out to you... It is hard to watch someone you love struggle, but she can get through this. Thank you for giving her the love and support she needs. :-)

      over 6 years ago
    • barryboomer's Avatar

      It seems Emend is the best so why don't all the Docs just give it before chemo?
      I think the drug he gave you is a Psych Drug BUT Don't EVER look at the side effects or you'll never take a Tylenol etc. Again.....

      over 6 years ago
    • Kathy1's Avatar

      Barryboomer you are right the Lorazepam is used to cut down on anxiety. When you have ongoing nausea and vomitting beyond the expected three days - you start to mentally react to getting chemo. I would just smell chemo and start getting sick. Its like Pavlov dog - your mind and body have been trained to react.

      over 6 years ago
    • karen1956's Avatar

      I don't recognize that med....I had horrid nausea with each chemo. I took all the pre-meds and any and all anti-nuasea meds Rx. I went for IV hydration and kytril and my onc Rx BDR suppositories...it was the best and thank goodness my DH was willing to administer it for me. BDR is benadryl, reglan and decadron. My local walgreens pharmacy was able to compound it for me. it worked much better than compazine for me. I also used Ativan. Hope things get easier for your wife with the next chemo.

      over 6 years ago
    • lujos' Avatar

      From what my doc here in Spain told me, Emend/Zofran are the big two to use post infusion.

      The Metoclopramide he gave me to take in between doses of Zofran, if need be. The lorazepam I took at night to help me relax and sleep, and it also has a mild effect on nausea.

      That's what my guy told me. I only had to take the Zofran, and only for a couple of days. The Metoclopramide has a pretty awful list of side effects (don't they all??), so I didn't take it -- but would have done so if the nausea was bad.

      over 6 years ago
    • jojo2's Avatar

      Besides the Emend I ended up on Zofran every 8 hours for the rest of my treatment including radiation. I weaned off after treatment was completed. Ativan helped me feel more normal if I felt shaky. I couldn't tolerate any ginger aids and favored grilled cheese sandwiches, Kraft Mac and Cheese, etc. all easily digested foods. Drinking water was a real issue for me, had to count glasses to remain hydrated. Extra fluid after chemo helped or some went back the next day for extra fluids. She will make it through this and feel better. jojo2

      over 6 years ago
    • barbdee's Avatar

      "Emend", a bag of it at infusion time. The medication comes in liquid IV & pill form. Many insurances will not approve due to the huge expense. Take any & all meds, if you read the side effects, we wouldn't even begin chemo. PREVENT IT!
      " Cosco" has the highest protein drink available. The name is "Premier", it may be the house brand. Nutrition is extremely important to healing. I ate twice toasted, dry English muffins, yogurt, crackers, soup, tea & string cheese. My wants changed every 15 minutes, so what I wanted today was not always what I wanted the next day.
      Bless you for being there for your wife. I would take a Xanax & Ambien, just to sleep, it will help calm her dread of vomiting & that's probably half the battle. All the best, Barb

      over 6 years ago
    • kashubian's Avatar

      The helplessness of being the "well" spouse is difficult to stomach. My husband had Emend for his first round, then ondansetron and prochlorperizine. He continued those through his pre & post surgical chemos. Also, after surgery, metochlopramide was added. For him it worked well. So did peppermint teas. When his nausea was worst, he was at his most dehydrated. In fact, dehydration was often a factor and we needed to make several trips to oncology or even the emergency room to get more fluids into him on occasion. Keep your nurse in the loop on the nausea. Both with his post-surgical chemo and post radiation we had to tweak his meds more than a few times to find a regimen that worked. I hope you find something that works. Hang in there.

      over 6 years ago

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