• Nausea meds - decadron, compazine, Zofran .....any experiences good or bad with these?

    Asked by HGWWW on Wednesday, October 24, 2012

    Nausea meds - decadron, compazine, Zofran .....any experiences good or bad with these?

    19 Answers from the Community

    19 answers
    • ticklingcancer's Avatar

      Zofran is probably the best anti-nausea medicine I took throughout my treatment. Phenergan works really well at night and also helps you to sleep. It can be taken with zofran because they're different types of medicine. Another good one is Emend. You would take this before you started treatment and it helps to reduce nausea for up to 5 days following. There are a couple of ways Emend can be taken. If your insurance will approve it, Emend is a good medicine to take.


      Good Luck with your treatment - Jimmy

      over 5 years ago
    • nobrand's Avatar

      I haven't had any issues with these meds-- they are lifesavers! I also agree that, of the oral meds, Zofran is the more effective choice if your nausea is bad. However, watch out... it slows your bowels (:

      over 5 years ago
    • Lirasgirl33's Avatar

      I take decadron and Emend before my Cisplatin/Taxol cocktail (chemo). Afterwards I take Emend, Zofran and Compazine. My doc said the Decadron is needed to prevent allergic reaction to the chemo. Emend and Zofran are great for nausea. Sometimes I have to take the Compazine too. When I'm on all these drugs and once the steroids have worn off I do feel dizzy/light headed, sleepy and like Nobrand mentioned, my bowels slow down. I end up having to change my diet to help with that.

      over 5 years ago
    • SueRae1's Avatar

      I have was given Emend before my infusions for for 2 cycles and it worked very well. I am now getting compazine, which is working fine. I have been very fortunate in that I have not needed to use the Emend prescription I got in July. My insurance covered to the cost my co-pay was $20 a pill.

      over 5 years ago
    • leepenn's Avatar

      I took them all. The nurses explained how I could use them together... which ones were compatible... timing... etc.

      With taxol and carboplatin plus abt888, I didn't really have that much nausea, and just zofran would do the trick (no drowsiness was a plus of that med). However, with AC, I was horribly nauseous, and I had to take everything... including Emend.

      The compazine was a sleep inducer for me. So, I only took that at night.

      The best piece of advice I received was to stay ahead of the nausea. If you let it take hold, it's tough to whack it back down. And if you start tossing your cookies, then you're in for a ride. I had only one cycle that was like what we see in the movies - one cycle out of 16... Not too bad, I suppose.

      Good luck. I hope you find the meds effective and your side effects minimal! Not everyone gets nausea!


      over 5 years ago
    • Nancebeth's Avatar

      I got Decadron through my IV before my chemo. I always took a Compazine when I got home whether I was nauseated or not. It also helped me sleep. The next morning I took a Zofram as a preventative, but I never got nauseated. I actually gained 10 pounds during chemo!

      over 5 years ago
    • HGWWW's Avatar

      Thank you all so very much for your responses! I appreciate the suggestions and all of the information!

      over 5 years ago
    • mgm48's Avatar

      I get nausea from the pain meds and compazine has worked well.

      Keep it positive and smile :)

      over 5 years ago
    • Kathy504's Avatar

      Zofran worked wonderfully during my chemo. If additional medicine was needed, I had compazine. I took Miralax throughout my chemo and radiation. Now I keep regular through diet -fresh pears and other fruit.

      over 5 years ago
    • booboo's Avatar

      I tried Zofran. It didn't do much for me and it was terribly expensive. I paid $1200 for 40 pills. The thing that helped me the most was marijuana. We now have a medical marijuana law in Connecticut so ask your doctor about this. It helped me when I was too nauseous to hold down an oral med. Good luck to you.

      over 5 years ago
    • myb's Avatar

      I used to get Zofran IV as premed for chemo and then had Zofran pills at home for the nausea. But I was still nauseous and it severely constipated me even with taking Senna and Colace and sometimes even Mirolax. Then I would swing to Diarrhea.

      My oncologist switched to Emend as premed and I took Ativan as an anti-anxiety which helped me to sleep through the 46 hrs of chemo pump of Folfox and helped me with nausea instead of Zofran. I would still take the senna and colace for the couple of days of chemo, but eventually even stopped taking them when I had oatmeal every morning for breakfast which regulated my bowels.

      over 5 years ago
    • HeidiJo's Avatar

      I took Zofran with no issues, and a mild sleeping pill if my nausea was really bad. I also used natural remedies which helped immensely. I tend to get very nauceous
      Canada Dry Ginger Ale ( the only ginger ale with real ginger)
      sea bands
      hot tea made with ginger root
      crystalized ginger
      you can get all these items at the grocery store

      over 5 years ago
    • Heather's Avatar

      Zofran is a life safer (I take it every 6 hours vs. 8 hours)! I take Compazine as a back up. My insurance won't cover Emend so it's 3 pills for $250 - but I heard it's pretty good too! Good Luck!

      over 5 years ago
    • bulldog's Avatar

      Zofran worked fairly well for me. Take as directed. Hang in- best wishes

      over 5 years ago
    • AmyC's Avatar

      I have had all 3 and I have had Phenergan and Emend. The decadron and Zofran I had via IV before chemo. The decadron worked great as a pre-med but the Zofran I was told would not work right away because it has to build up in your system before it works well. It worked ok on me, but then again I took it durring my bone marrow transplant which was pretty tough and so I had to take Phenergan as well which I have learned through trial and error is my magic pill all on its own through 3 different chemo treatments (RCHOP, RICE, BEAM). The Emend did not work on me, but the doc warned me ahead of time he's found it's a 50/50 type of drug, but for the 50% it works on it's supposed to be amazing. Long story short.....I LOVE PHENERGAN! :) Its also calms and relaxes you as ticklingcancer said so taking it at bedtime is best until you're used to it then the sleepiness isn't bad at all. GOOD LUCK!!!!!

      over 5 years ago
    • Fusionera's Avatar

      Hi HG,

      I have had experiences with all three of those drugs at different times with my cancer. Compazine was completely ineffective for me, while Zofran was great. Decadron is a corticosteroid and while effective for nausea can also cause severe constipation. I was on Decadron most recently for nerve pain but its efficacy wore off after a while; I then switched meds. The best anti-nausea meds I used were Zofran, Kytril, and Emend, sometimes in combination. I was on a clinical trial and required particularly strong meds to counter the effects of the chemo. If Zofran is not strong enough, I highly recommend Kytril. Hope this helps.

      over 5 years ago
    • Myungclas' Avatar

      I agree with tickling cancer. Zofran and phenargan worked well for me.

      over 5 years ago
    • joantri's Avatar

      Here is my experience-depending on the chemo, my need changed with what worked or what didn't work. I could not take compazine since I had a strange reaction. Decadron is a steroid and could only take a teeny bit 4mg or I would be wired for days. Zofran did help at first, but I have been in treatment for 2 1/2 years, so it helps in combination with my favorite drug Reglan. Reglan stops nausea, but DOES not make you constipated which is the problem with the anti nausea meds. Also, Emend is one I take with every chemo. I used to get Aloxi in my IV, but stopped and replaced it with Kitral. Kitral is a pill and I take that an hour before an infusion. For horrible nausea, I also took Sancuso patch which is useful specifically for chemo induced nausea. It is expensive, but often doctors have samples depending on where you go for chemo. Unfortunately, you have to figure out what works for you. Reglan is something that my nurse recommended and I find it takes the nausea edge off.

      over 5 years ago
    • wheezyCough's Avatar

      Decadron is a corticosteroid is not for nausea, compazine helps when combined with phenergan but when taken with reglan strongly increases the risk of normally very rare reactions called neuroleptic malignant syndrome, dystopic reactions including tardive diskensia which can become permanant (so watch out for continuous odd worming tongue motions you didn't make before as well as lip smacking and other motions you find you uncontrollably continually do...and why nurses shouldn't recommend meds...no offense but it's why when My pharmacist tries I say "leave that up to My doc please, it is his job afterall to prescribe My pills, you provide them and count them" as I find more and more pharmacists are attempting to create a niche for themselves that cannot be replaced by a pill - sorting and counting machine, as I'd really prefer as machines don't make mistakes (you can report pharmacists and techs that do and you should, I've had far too many give Me the wrong meds altogether, eve. At cvs, so I go to a mom and pop pharmacy cuz I find they give MUCH BETTER customer service), and zofran helps if My nausea is severe enough. I apparantly cannot take emend, kytril, or aloxi as apparently they affect My antidepressant. I too take Ativan for the anxiety during chemo and used to take Marinol (THC in a pill) but since Michigan now has medical Marijuana I just use the edibles as smoking Marijuana isn't agreeable with My emphysema, copd, and lung cancer (which I got from smoking in the first place...quit...now). If you do have Medical Marijuana and can afford it (it's actually quite expensive which is why I don't get people carrying on about drug costs then saying "So I chose marijuana" as its the most expensive thus far. It'd be nice if these were the prices from My youth, but I hear you pay for potency (and apparently for popularity as well as I'd love to know what chronic illness most of these youngsters have that I see in the dispensary. I think it's ridiculousness)

      over 2 years ago

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