• Neulasta Bone Pain and Claritin

    Asked by msesq on Tuesday, February 13, 2018

    Neulasta Bone Pain and Claritin

    Interesting article that concludes Claritin isn't really a remedy for Neulasta bone pain:
    https://medivizor.com/view_article/11313322?utm_campaign=website&utm_source=sendgrid.com&utm_medium=email

    17 Answers from the Community

    17 answers
    • GregP_WN's Avatar
      GregP_WN

      Wow, people on this site have been saying that it works for years. I've never had to try it, so I can't say.

      3 months ago
    • jackiwalkr's Avatar
      jackiwalkr

      I used it. It works wonderfully. I was skeptical but it worked.

      3 months ago
    • msesq's Avatar
      msesq

      I tried it and it seemed to help a little and now I am wondering if it was the placebo effect

      3 months ago
    • geekling's Avatar
      geekling

      Cant comment.

      Havent tried it and dont intend to try it either

      3 months ago
    • barryboomer's Avatar
      barryboomer

      They are full of it.

      3 months ago
    • jackiwalkr's Avatar
      jackiwalkr

      Wow, not cool. It really works. I had probably 15 to 20 shots of neulasta and neupogen. I can't believe how fast someone is negative. Barry I think you are full of it!

      3 months ago
    • Ejourneys' Avatar
      Ejourneys

      First, the study had 600 subjects. That sounds somewhat robust until you realize that they were divided into three groups of 200. That number is fairly decent, but still. As the original study (not Medivizor's distillation) says, "All patients in the study were women and had early-stage breast cancer, so these results may not translate to men or other tumor types and stages. Subgroup analyses were based on stratification factors at randomization, and treatment did not always align with stratification." (Source: https://link.springer.com/article/10.1007%2Fs00520-017-3959-2)

      Second, the groups received Claritin (loratadine) ALONE, or Aleve (naproxen) ALONE, or no treatment (not even a placebo). My chemo nurse had told me to take both Claritin (regular, not D; the study doesn't specify which one they used) AND Tylenol (rather than Aleve) TOGETHER, both on the day of chemo and for 4-5 days thereafter.

      Third, dosing in the study began on the day Neulasta was administered, not before, and that can make a difference. From the original study article:

      "Prophylactic naproxen or loratadine was administered orally for 5 days in each of the first 4 chemotherapy cycles, beginning on the day patients received pegfilgrastim. Naproxen (500 mg) was administered twice a day, in the morning and in the evening. Loratadine (10 mg) was administered once a day in the morning."

      I started taking Claritin and Tylenol TOGETHER on chemo day, i.e., THE DAY BEFORE my Neulasta shot.

      Fourth, THIS WAS NOT A FORMAL STUDY, but a preliminary one. From the original study article:
      "This was an estimation study, and it was not powered to demonstrate a statistically significant difference between treatment groups for any endpoints. Differences between treatment groups were not tested formally, and P values are considered nominal....Since the study did not test any formal statistical hypotheses, no controls for multiple comparisons were employed....As this was an estimation study, and controls for multiple comparisons were not employed, results of the subgroup analyses should be interpreted with caution." The article details other limitations as well.

      Shame on Medivizor for framing the results as though they came from a formal study. Anyone who does not check the original study article is likely to be misled. (On the bright side, the original study article is not behind a paywall, but can be accessed for free from the Medivizor site.)

      I had no Neulasta pain at all. Obviously I can't say whether I would have had pain if I had not taken Claritin and Tylenol as directed, but the bottom line for me is that I had no pain.

      Here's more on the use of Claritin with Neulasta:
      http://www.omgihavecancerwhatdoidonow.com/2013/08/claritin-may-relieve-bone-pain-caused.html

      3 months ago
    • PaulineJ's Avatar
      PaulineJ

      I wish something would work for me for all my conditions.I'm allergic to 21 medications.

      3 months ago
    • geekling's Avatar
      geekling

      There is likely a plant or multiple plant remedy which will improve the condition your conditions are in PaulineJ

      3 months ago
    • PaulineJ's Avatar
      PaulineJ

      geekling I don't think so.

      3 months ago
    • BuckeyeShelby's Avatar
      BuckeyeShelby

      Before she realized my leg pain was a Taxol thing and not a Neulasta thing, my nurse case manager suggested Claritin.

      3 months ago
    • geekling's Avatar
      geekling

      @PaulineJ, I know you are fond of Jesus.

      Before drawing up conclusions, try looking up Matthew 8:13

      3 months ago
    • PaulineJ's Avatar
      PaulineJ

      geekling It's not that either.Been having trouble with doctors not being there for me as I get older.Plus it's the surgeries more or less that messed me up.Plus doctors taking their big time ,before I have gotten anything done>like test,apps and such.It always seems to be a big process.But now I'm being promised the moon(Just a saying for them being dishonest on getting a orthodontist since last July and not calling me back.And so much more.Since 2012 I was getting radiation and had to get bridges for my whole top according to a dentist I was seeing That was a very long process.ThenDec. 2015 >6 bridges came out and that was a nightmare 'til Feb.2016 to even get an app for surgery.And they sent me to Ma.Gen . to a resident that claimed she was a surgeon to do the surgery.I was told that I wasn't a candidate for general anesthesia or inplants because of my age and conditions.So I had to go with the flow into getting dentures.That took 'til July 2017.He told me he gave me the dentures 'til I get my inplants which I wasn't a candidate for. I 'm very frustated on and off since 1998 on the colon surgeries.(having too much problems getting more frequent and more worst.Heart leaks from open heart surgury and the cardiologist is leaving in March .He's one out of 3 that I really like and 1 out of many doctors left from this particular hosp so far.There's just the surgeon left over there.And there's so much more that it would take me a lifetime to explain.

      3 months ago
    • PaulineJ's Avatar
      PaulineJ

      I forgot about the bad pain I can't take anything for since 2010 from the back surgery that gave me many problems and getting really worst since.I now have pain from spine down worst,one shorter leg then the other,bent from back and bad circulation in legs and feet from both back and heart surgeries.

      3 months ago
    • gpgirl70's Avatar
      gpgirl70

      I know that Claritin works for Neulasta associated bone pain. I took Claritin and Tylenol starting the day of chemo. I would take the Claritin for 6 days. I never had bone pain at all. Well, on my third chemo, I got a bit lazy about the Claritin because I'd never experienced the bone pain. I stopped taking it after 3 days. Oh holy cow, then I knew what bone pain was. It was excruciating. I started the Claritin right away again and it helped tremendously although didn't clear it completely. On my 4th chemo, I took it like before and no bone pain. I really don't give a blankety blank whether it was a placebo effect although I know it wasn't. When I took Claritin no bone pain, when I didn't extreme bone pain.

      3 months ago
    • JustForToday's Avatar
      JustForToday

      Like gpgirl70 I lapsed once with the Claritin that was promoted by my treatment center after Neulasta injections. I experienced significant thigh bone pain. After taking the Claritin the pain went away later the same day. I also was diligent about taking my Claritin for the next Neulasta injection. I do not believe this was a placebo effect.

      3 months ago
    • akwendi's Avatar
      akwendi

      Placebo or not...it helped to get me through it! The first chemo when I didn't know about it was horrible. The remaining sessions I used the Claritin and got through the bad days much easier.
      That's really all that matters to me :)

      3 months ago

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