You sound anemic!!!! Are you out of breath when you have to stop walking? Talk to your health care providers about this!!! I totally had this side effect - I'd go up one flight of stairs and have to rest before walking down the hall to my office... Bah - not fun. For me, it was manageable... but not fun. Sometimes, I just had to close my office door and lay down for a few minutes.
Anyway, one of the big challenges I had with my last two cycles of treatment was how much worse the second to last one was compared to the others... and then how much worse the last one was compared to the others... The last cycle really knocked me down. I'm sure I got really low on the hemoglobin... I had major fatigue... and nausea.
Ankles swollen - talk to your doc for sure!!!! In fact, I would say that one is worthy of a phone call to the clinic TODAY!
Good luck. I'm sorry you're dealing with these side effects. They suck!