Do you have a second opinion? My experience is only with aggressive lymphoma, but once the cancer has defeated a drug (meaning, only those cancer cells not affected by the drug remain), it usually does not respond a second time. In the case of lymphoma, the second use of a drug would lead only to damaging the patient's health, rather than the cancer itself. This is one in which a second opinion could make quite a difference.

Outstanding answer by po18guy. I would definitely not hesitate to get a 2nd opinion. And, don't worry about the 1st docs ego. The good ones are very open to the idea of patients seeking 2nd opinions.

Most large cancer treatment facilities have "tumor boards" in which they brainstorm treatment strategies amongst their various doctors. If the doctors seek second opinions, it is certainly appropriate for the patient to do so.

Thanks for the responses. She is being seen at OHSU in Portland where a tumor board actively reviews her case. Additionally, last year we consulted with physicians at UCLA. In this case she stopped taking the drug after 10 days due to a bad reaction to the drug. My understanding is that there is a trial underway that is looking at whether Sorafenib/Nexavar is beneficial in cases where the patient has had liver resection surgery, but it isn't yet known. Nexavar/Sorafenib has been touted as almost a miracle drug for liver cancer, in part because no other drugs have worked so well at inhibiting tumor growth. Our daughter will have follow up scans in a few weeks and we'll evaluate then.

My father's oncologist has also praised it as the most effective liver cancer treatment out there. If you can handle the side effects. My father was unable to take it because the side effects were too severe. he started with diarrhea, and it turned into nausea, lack of appetite, eventually hospitalizing him for pain and dehydration. Does your daughter get side effects? If she can handle them, i would say it's worth the shot to to try again! Good luck to all of you! hang in there and God bless you!