• PD-1 Trial?

    Asked by tmlovett on Tuesday, February 26, 2013

    PD-1 Trial?

    I just finished my 2nd round of Yervoy w/ no real imrpovement. My doc wants to put me in a PD-1 trial that would start in about a month or so. Thoughts? Experiences? I'm not feeling terribly optomistic about any options available.....

    4 Answers from the Community

    4 answers
    • Peroll's Avatar

      First you need to know what the signs of a treatment working are. If you cancer does not grow during a treatment then it is considered partially successful as it is preventing growth. I know that this is not really comforting as you what to get rid of the cancer, but if the current treatment is keeping it in check then waiting for a month using the current treatment is not a big deal.

      When going into a trail you need to be fully informed as to how the trial is being run and whjat to expect. This means asking a lot of questi9ons. In trials either everyone is given the new drug or some are given the new drug and some are given the olf treatment and they don't tell you which you will get. If the old drug holds it at bay then thee isn;t much to loose but if it is growing on the old drug you want to maximize the chances of getting the new drug. You also need to know the risks that the new drug entails. Often it is difficult to know what the side effects will be going ibnto the trial and there may be real risks involved. Get all of the information you can before making a decision.

      That being said trials can and do offer the hope of breakthrough results that may help you and iof the current treatment is not getting the results you want then they are deffinatly worth a go. If thing aren't working out then you can always drop out. You also usually get monitored much more closely during a trial and at reduced or no cost to you so that is a plus. Good Luck

      over 4 years ago
    • carm's Avatar

      This study does look promising and to date there have been some favorable reviews in peer reviewed publications. I think that your doctor has your best interests at heart and I think it is noble of anyone who joins a study in the hopes of advancing medicine. It it were not for study participants, I don't think we would have half of the meds that are on the market today. I have attached a link regarding the study. I hope this will help answer any questions for you, Carm RN.


      over 4 years ago
    • Dick_K's Avatar

      I do not have any first hand PD-1 information to pass on but I can echo the comment that you will probably get a higher level of care as part of a clinical trial. I am 36 months into a phase II trial even though the drug I’m on, Zelboraf, got FDA approval in August 2011.

      That having been said, there is a very good webinar about PD-1 at the Melanoma International Foundation. If you go to the following link, on the top banner you will find a drop down box for a number of webinars; PD-1 is one of them.


      Regardless of your PD-1 decision, I would like to wish you the best of luck. There are just too many important events coming with your children and you need to be there to enjoy them.

      over 4 years ago
    • tmlovett's Avatar

      thanks to all of you. I appreciate the info and links. I will find out at my next PET/CT in about a month how effective or ineffective the Yervoy was. I'm not optomistic as I can palpate all the tumors and then some from the start of treatment. Considering this clinical trial is for another immunotherapy I'm concerned that it's not going to be effective for me as I'm already not responding to the Yervoy. I'll have my slew of questions for my doc in 3 weeks! thanks again :)

      over 4 years ago

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