• R CHOP didnt work what can I except next

    Asked by Rosco04 on Sunday, March 3, 2019

    R CHOP didnt work what can I except next

    5 Answers from the Community

    5 answers
    • GilDBA's Avatar
      GilDBA

      I started with RCHOP but mid way (after 3 rounds), the dr was not happy with the progress and I switched to Hyper CVAD. In my case 2 rounds (each round has a an A and B cycle). It was very intense and much harder to go through in comparison to RCHOP, but it seemed to do the trick so far. It has been 14.5 months since my last chemo and so far so good.

      7 months ago
    • Schlegel's Avatar
      Schlegel

      Keep the faith. Today there are many treatments to choose from.

      7 months ago
    • carm's Avatar
      carm

      @Rosco04,
      Hello, I am an oncology nurse and the NCCN guidelines for 2nd line therapy are R-GDP or R-ICE if you are a transplant candidate and BR, R-GDP, or GemOX if you are not a transplant candidate.

      7 months ago
    • judithj's Avatar
      judithj

      Hang in there. I was diagnosed with double hit (aggressive) diffuse large B-cell lymphoma on Feb. 2018. I was put on R-CHOP for 4 (out of 6 planned) sessions when my tumors were found to be 'refractory'. I asked for a second opinion at UCSF and was then directed to R-EPOCH. Much harder therapy and, eventually, also not effective at eliminating all tumors. I was put on a 'palliative' chemo of R-
      GEM-OX. Because I had failed 2 lines of therapy I was now eligible for immunotherapy (CAR-T). My Oncologist presented my case to a board of (Kaiser) doctors. They agreed to OK me for evaluation at Stanford for CAR-T therapy. I am 76 years old but passed all tests and went through CAR-T on Nov. 21, 2018. It's not easy but very effective.
      I have had 2 clear PET scans since then and have no evidence of disease (NED). It was a long haul but if I can do it so can you. Keep asking questions and asking for second opinions if necessary. Ask about other forms of chemo, never quit. There are new gene therapies being discovered, keep going - we here are all behind you and cheering you on!

      7 months ago
    • po18guy's Avatar
      po18guy

      One less toxic alternative to the various salvage therapies (don't you love that term?) is known as TREC. It consists of Treanda (Bendamustine), Rituxan, Etoposide and Carboplatin. It did an absolutely remarkable job in my case - eliminating two dozen tumors, spleen and small intestine involvement in just two infusions. There is every indication that it can be just as effective against B-cell lymphomas. The caveat here is that I was treated for two sub-types of substantially different T-Cell lymphomas as well as a bone marrow cancer (MDS).

      It removes the Ifosfamide in ICE and replaces it with Bendamustine. It is given on an outpatient basis, rather than in-patient, as is the case with ICE. Any time one can avoid hospitalization is very good.

      7 months ago

    Help the community by answering this question:

    Create an account to post your answer Already have an account? Sign in!

    By using WhatNext, you agree to our User Agreement, and Privacy Policy


    Read and answer more diffuse large b-cell lymphoma questions.  Also, don't forget to check out our Diffuse Large B-Cell Lymphoma page.