I am sure people will be weighing in soon. After reading your whole question I noticed that you were seeking feedback on Zometa. I entered "Zometa" in the search box next to Questions on the top right of this page and found we had several conversations about this drug. Here is the link: http://whatnext.com/questions?utf8=✓&question_query=zometa
I hope you'll find some helpful information in here.