I am not sure what you mean by "big time". I have Metastasized TNBC and Kidney Cancer on my liver. I have been on 5 different chemo regimens since July 2009, when the Kidney Cancer was diagnosed. I just started my third chemo since May of last year, when the Breast Cancer was found. It is a clinical trial using two oral medications. My cancers were responding to treatment but the Carboplaint, Gemzar & Avastin combo I started in July was just too much for my Platelets.
There is so much research, trials, and new treatments being approved and/or in the pipeline, the is reason for much cautious optimism.
Prayers and healing vibes to both you and your sister.