• Stage IV melanoma. Zelboraf didn't work. IL2 almost killed him. Now we are going to try Avastin and Temodar together...what to except. Pleas

    Asked by createdone on Saturday, April 13, 2013

    Stage IV melanoma. Zelboraf didn't work. IL2 almost killed him. Now we are going to try Avastin and Temodar together...what to except. Pleas

    I am curious about these meds together...Has anyone else taken these meds??

    2 Answers from the Community

    • carm's Avatar
      carm

      Createdone,
      So sorry to hear that Zelboraf did not help. Temodar is a long established drug. In chemotherapy, it is an alkalayting agent that works on the resting phase of the cell cycle to try and stop it from proliferating. Avastin is not a chemotherapy, it is a biotherapy. It does not destroy cells, it blocks the receptor site on the tumor that gives off a message that it needs a blood supply. This starves the tumor. Temodar has the usual side effects like nausea and is best taken on an empty stomach. Avastin will raise blood pressure and kidney function should be monitored but the infusion only takes about 20-30 minutes and maybe an occasional muscle ache but no hair loss or other side effects that you would see with a chemo. I think he will do quite well. Best of luck to you both, Carm RN.

      almost 4 years ago
    • StrongSteph's Avatar
      StrongSteph

      I took temodar as a part of the biochemotherapy treatment. Being a chemotherapy drug it was a bit hard to stomach. (I was on a total of 5 drugs). Are you able to try Yervoy aka ipilimumad? SO sorry to hear that! I had about IL-2 and it was very hard for sure.

      almost 4 years ago

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