• The use of unirradiated blood products with patients who have Acute Lymphoblastic Leukaemia

    Asked by KevinG on Monday, November 19, 2012

    The use of unirradiated blood products with patients who have Acute Lymphoblastic Leukaemia

    Here in Wales / Britain, Cerys was in the UK Acute Lymphoblastic Leukaemia Trail 2003.
    It has now come to my attention that under the Trail, they were allowed to give Cerys unirradiated blood product. I have a letter that says they can.
    My reason for writing is that this would have put Cerys at risk of transfusion associated graft -versus-host disease. There is nothing in Cerys' medical notes to say she contracted this disease.
    My thinking is however, that the use of unirradiated blood product, would work to Cerys' disadvantage, in that Cerys' remission would be shortened,she only managed 18 months
    with life after diagnosis?
    Was the use of unirradiated blood product allowed to be used in your or your relatives chemotherapy treatment?
    Or is the answer a definite no,no?
    Thank you.

    3 Answers from the Community

    • nancyjac's Avatar

      I didn't have Leukemia, but I didn't have any blood products with my chemo. I did have blood transfusions with my subsequent surgery, but I don't know if it was irradiated or not.

      almost 8 years ago
    • Harry's Avatar
      Harry (Best Answer!)

      Did she have a bone marrow transplant? That's the only reason I can think of to give "blood product" and to have a concern about graft versus host diseast.

      I suspect this question is too technical. You might be best off talking to a doctor who was not involved with the original trial.

      If this involved a bone marrow transplant from an unreleated donor, then it is my understanding that those types of transplants carry both an improved chance for complete cure/remission, but also an elevated risk for failure and death.

      I don't know what the benefits of irradiated or unirradiated blood might be. It may be that irradiation is used to prevent the transfer of infection (AIDS) but I don't know how it would affect transplant rejection. Again, an expert on the subject who was not involved with the original trial may be your best source of information.

      almost 8 years ago
    • amandakrystyne's Avatar

      My daughter has had numerous transfusions. I am now curious on this topic, but unfortunately do not have an answer for you. :0 /

      over 7 years ago

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