• what chemo protocol works for Ovarian cancer (stage 4)?

    Asked by Jade on Sunday, August 5, 2012

    what chemo protocol works for Ovarian cancer (stage 4)?

    I am currently in a clinical trial... not even sure I am getting the meds or the placebo... but would appreciate hearing from anyone else who has been through this cancer.

    4 Answers from the Community

    4 answers
    • Cindy's Avatar

      I had 6 chemo treatments of Paclitaxel (Taxol) and Carboplatin spaced 3 weeks apart for Ovarian cancer. I received the chemo in a doctor's office and it took about 6 hours each time. First I got several drugs to counteract the side affects of the chemo drugs. They first gave me the Taxol very slowly because it was the most toxic of the two. Then they gave me the Carboplatin much faster. Initially my doctors thought I was stage 3 and were wanting me to get a port in my abdomen to put the chemo directly in my abdomen and pelvis. After the lab results came back after my surgery, they determined that I was stage 2 and that it would be okay to get the chemo via a port in a vein in my chest. If I got the port in my abdomen, I would have had to travel about 3 and a half hours (one way) to another city to get it done and be part of a clinical trial. I opted to do it via a vein and get it done locally. So far, I have had no evidence of cancer since my surgery on November 2010. My last chemo treatment was March 17, 2011.

      about 8 years ago
    • carm's Avatar

      Hello Jade, I am an oncology/end of life nurse that specializes in gyne cancers so let me lend some information to this discussion if I may. Cindy is correct in that Carbo/Taxol is the gold standard of care in Ovarian cancers. It is usually a first line defense in treating cancers such as this. There are other treatments such as a chemo agent used along with a biologic such as Avastin (bevcuzimab). Avastin is a drug that halts the production of angiogenesis to a tumor. By cutting out the blood supply, the tumor starves. Anothert newly drug in the arsenal are PARP (poly ARP ribose polymerase) Inhibitors. These drugs repair any damage to a single strand DNA before it divides and multiplies thereby eliminating any mutation on a double strand DNA. They have been very effective. If you are in a study, I doubt there would be a placebo arm so it is rare, albiet it does happen. Most oncology studies are comparative studies (one agent vs another or one agent alone vs a combination of agents). Always make sure that the study you join is a phase III or IV so that you can be assured the drug is showing promise already. I hope this helps, good luck, Carm.

      about 8 years ago
    • Carol-Charlie's Avatar

      Welcome to where you never wanted to be. I think you'll be glad you found this great site. My name is Carol and I too was diagnosed wiht Stage IV Ovarian Cancer back in January of 2006. I was 62. My Gynicological Oncologist Surgeon (Was a very new specialty back then) removed the ovaries, one of which was a 39lb tumor. He then painstakingly removed the cancer from my intestine and my euretha. As he said, I removed all that I could see. Later we discovered he had removed all of the cancer. We did a very aggressive chemo consisting of I/V infusions and I/P (Inter Peratineal) invusions through a port he had implanted within my abdomin during surgery. I had six cycles of 28 days. Day one I/V infusion, Day Two I/P infustion, Day eight I/P infusion...then at the end of the 28 days start over with I/v ect. After completing that I received one infusion of a very strong chemo once a month for 12 months. I'm now 69 and, of course, very blessed. I remain cancer free. Don't let the words "Stage IV" terrify you. They did me, I knew quickly that Only God could help my fear. Just before they told me what I'd already figured out what I had.... I told God how terrified I was and asked him to take my hand and lead me to where he wanted me to be. My trembling fear left instantly and he has lead me to her... six and half years later. My CA125 showec no cancer markers... and life is good,. If you'd like to talk... I'm here.

      about 8 years ago
    • SpunkyS's Avatar

      I hope you have had some of your questions answered in person. I was diagnosed at stage IV. I recently finished the first part of a clinical trial using Carboplatinum and Taxol. Before this were several intravenous meds to decrease or prevent reactions. The intravenous Benadryl made me sleep through most of chemo. My lips did not match about 10 mins after administration of Benadryl. My support person would giggle and I knew it was time to stop talking and go to sleep. Added to the chemo regimen in the trial was Avastin every 3 weeks. All if it was through a mediport. I was afraid to get the mediport placed. Not a deal as I look in hindsight. Heck, after debulking surgery I don't know why this scared me.

      At first I was randomized to the every week chemo and every 3 week Avastin. After several delays in chemo due to bone marrow suppression and low counts --- GRRR, and learning patience, I finished my last 2 chemos on the standard 3 week cycle.
      The infusion nurses told me that I was the only person they knew who begged to have chemo. At one point when my counts came back up and I could have chemo I promiesed them I would not dance on their desk nor use the long, newly waxed floor of the chemo bay as a bowling alley if they let me have chemo.
      I am now at the Avastin lonly stage. Every 3 weeks for a year or until progression.

      about 8 years ago

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